The paper reviews neutron sources, chemical compounds and clinical perspectives of the boron neutron-capture therapy of brain tumours. Special attention is paid to the physical characteristics and biological effectiveness of the epithermal neutron beam constructed at the LVR-15 nuclear reactor at Rez near Prague.
"Modern nuclear reactor based epithermal (0.5 eV-10 keV) neutron beams fulfil the requirements for effective BNCT with neutron fluxes of about 10 9 neutrons/cm 2 s (e.g. Perks et al. 1988, Moss 1990, Rogus et al. 1994, Liu et al. 1996, Burian et al. 1997, Moss et al. 1997, Auterinen et al. 2001, Kortesniemi 2002, Seppälä 2002). "
[Show abstract][Hide abstract] ABSTRACT: Purpose: A Phase I trial of cranial neutron capture therapy (NCT) was conducted at Harvard-MIT. The trial was designed to determine maximum tolerated NCT radiation dose to normal brain.Methods and Materials: Twenty-two patients with brain tumors were treated by infusion of boronophenylalanine-fructose (BPA-f) followed by exposure to epithermal neutrons. The study began with a prescribed biologically weighted dose of 8.8 RBE (relative biologic effectiveness) Gy, escalated in compounding 10% increments, and ended at 14.2 RBE Gy. BPA-f was infused at a dose 250–350 mg/kg body weight. Treatments were planned using MacNCTPlan and MCNP 4B. Irradiations were delivered as one, two, or three fields in one or two fractions.Results: Peak biologically weighted normal tissue dose ranged from 8.7 to 16.4 RBE Gy. The average dose to brain ranged from 2.7 to 7.4 RBE Gy. Average tumor dose was estimated to range from 14.5 to 43.9 RBE Gy, with a mean of 25.7 RBE Gy.Conclusions: We have demonstrated that BPA-f-mediated NCT can be precisely planned and delivered in a carefully controlled manner. Subsequent clinical trials of boron neutron capture therapy at Harvard and MIT will be initiated with a new high-intensity, high-quality epithermal neutron beam.
International journal of radiation oncology, biology, physics 08/2002; 53(5):1361-1379. DOI:10.1016/S0360-3016(02)02862-6 · 4.26 Impact Factor
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