Article

Withdrawal reaction associated with venlafaxine.

Nottingham Healthcare NHS Trust, Wells Road Centre, Nottingham NG3 3AA.
BMJ Clinical Research (Impact Factor: 14.09). 10/1998; 317(7161):787.
Source: PubMed

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Available from: Walter P Bouman, Jun 06, 2015
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    ABSTRACT: Introduction Venlafaxine is an antidepressant that selectively inhibits serotonin reuptake and is a norepinephrine inhibitor. Withdrawal syndromes can occur after abrupt drug discontinuation of long-term regimens. Exegesis We report six cases of withdrawal symptoms after venlafaxine discontinuation. Conclusion Physicians must be aware of the frequency, rapidity and potent severity of these withdrawal syndromes.
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    ABSTRACT: Venlafaxine is an inhibitor of neuronal serotonin and noradrenaline re-uptake and a weak inhibitor of dopamine re-uptake. There was no indication of problems of abuse/dependence during the clinical trials. A 53-year-old client with a history of alcohol and amineptine misuse and a long history of recurrent depression, for which he was prescribed venlafaxine tablets. Over time, he increased the dosage to 50 tablets daily (3750 mg). Large venlafaxine dosages produced amphetamine-like effects, due possibly to the related increase in dopamine turnover. Once hospitalized for detoxification, the patient had a symptomatology which was consistent with a serotonergic discontinuation syndrome. Physicians should be aware that patients with a history of drug and alcohol abuse might develop venlafaxine dependence.
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