Theoretical note: tests of synergy in sweetener mixtures.

Department of Food Science, Cornell University, Ithaca, NY 14853, USA.
Chemical Senses (Impact Factor: 3.28). 09/1998; 23(4):447-51. DOI: 10.1093/chemse/23.4.447
Source: PubMed

ABSTRACT Some methods for examining the additivity of sweeteners, and their synergy in mixtures depend upon setting component concentrations on the basis of sweetness equivalence, usually to a sucrose reference. These methods may under- or over-predict the sweetness of a mixture, leading to spurious claims of synergy or mixture suppression. This paper points out one problem with one such popular method, in that the method can lead to a conclusion that a substance would synergize with itself. To the extent that self-synergy is an illogical conclusion for a mixture comparison, such a method should be avoided in tests of synergy. The sweetness equivalence approach is contrasted with a simpler approach based on concentrations that does not lead to conclusions of self-synergy.

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