Article

[The persistent negative potential provoked in different structures of the rat brain by a single wave of spreading cortical depression].

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (impact factor: 0.33). 48(4):654-63. pp.654-63
Source: PubMed

ABSTRACT The persistent negative potential (PNP) developed after a single wave of cortical spreading depression (SD) in the cortex, hippocampus, thalamus, and caudate nucleus. The PNP lasted for about 3-4 hours, its amplitude was 6-7 mV in the ipsilateral and 3-4 mV in the contralateral structures. After development of bilateral primary cortical SD waves the amplitudes of the respective PNP were summed up and reached 9-11 mV. However, after the repeated waves of cortical SD produced with 15-30-min intervals, the PNP level remained unchanged. We think that the PNP is an electrographic manifestation of the well known persistent vasoconstriction after a single wave of cortical SD. It seems to be related with reticular activation due to functional decortication.

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Keywords

15-30-min intervals
 
3-4 hours
 
amplitudes
 
bilateral primary cortical SD waves
 
caudate nucleus
 
contralateral structures
 
cortex
 
cortical SD
 
electrographic manifestation
 
functional decortication
 
known persistent vasoconstriction
 
persistent negative potential
 
PNP level
 
SD
 
single wave