Article

Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans. HIV Neurobehavioral Research Center Group (HNRC).

Department of Neurosciences, University of California, San Diego, USA.
Neuroscience Letters (impact factor: 2.11). 10/1998; 254(1):1-4. pp.1-4
Source: PubMed

ABSTRACT We measured the concentrations of the neuron-specific protein, tau, in the cerebrospinal fluid (CSF) of 32 neurologically characterized HIV-infected (HIVpos) subjects and nine matched seronegative (HIVneg) controls using a sensitive ELISA assay. Of 32 HIVpos subjects, nine had HIV-associated neurocognitive disorders, and nine had clinically diagnosed peripheral neuropathies. CSF tau levels in subjects with HIV-associated neurocognitive disorders were similar to those in HIVneg subjects (185 +/- 83 vs. 223 +/- 106 pg/ml; P = 57). CSF tau levels in HIVpos subjects with peripheral neuropathies did not differ from those without neuropathies (320 +/- 190 vs. 251 +/- 185; P = 23). In summary, CSF tau levels were not elevated in patients with HIV-associated neurologic disease.

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Keywords

32 HIVpos subjects
 
32 neurologically
 
cerebrospinal fluid
 
CSF
 
CSF tau levels
 
HIV-associated neurocognitive disorders
 
HIVneg subjects
 
HIVpos
 
HIVpos subjects
 
neuron-specific protein
 
neuropathies
 
patients
 
peripheral neuropathies
 
sensitive ELISA assay
 
tau
 

R J Ellis