"Subsequent research indicated that the leucopaenia was a consequence of pulmonary sequestration of the cells mediated by the contact of blood with the membrane surface (Craddock et al. 1977). It is now well accepted that C3a, C5a, and the terminal complement complex (TCC) stimulate the expression of receptors on leucocytes, leading to aggregation and sequestration in the pulmonary microvasculature (Dhondt et al. 1998). The desire to minimize these responses resulted in the modification of the classical cellobiose unit of the cellulose strands in which the OH groups are either replaced or the blood contacting surface is coated by materials such as poly-ethylene glycol (PEG) to minimize blood exposure to the hydroxyl groups on the surface (see Fig. 3 "
[Show abstract][Hide abstract] ABSTRACT: Films and tubes manufactured from cellulose have historically been used in the treatment of renal failure, but their use for this purpose has declined in recent years in favour of films manufactured from synthetic material blends. As the clinical application of cellulose for dialysis declines, new applications for its use are emerging, of which the most promising appears to be the use of microbial cellulose synthesized by Acetobacter xylinum as a novel wound healing system and as a scaffold for tissue regeneration.
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