Etiology and pathogenetic mechanisms of optic disc swelling with visual loss. An interdisciplinary prospective pilot study of 102 cases.

Department of Ophthalmology, University of Düsseldorf, Germany.
Ophthalmologica (Impact Factor: 1.68). 02/1999; 213(1):40-7.
Source: PubMed


A nonrandomized, prospective, interdisciplinary pilot study of 102 patients with noncompressive optic disc swelling with visual loss (ODSWVL) was performed in order to investigate etiologic and pathogenetic mechanisms. Forty-six patients suffered from underlying inflammatory disease. Seventeen patients suffered from highly probable cardiogenic embolization, 16 patients from multiple vascular risk factors. The remaining patients of the noninflammatory disease group suffered from leukemia, previously unknown or severely decompensated diabetes mellitus, acute arterial hypertension, different kinds of coagulopathies and others. Ninety-six of the 102 patients required medical treatment according to general medical standards. Inhomogeneity of the underlying disease processes explains the ineffectiveness of different monotherapies in previous studies. Interdisciplinary search for the underlying causes allows causative treatment. ODSWVL and anterior ischemic optic neuropathy in particular seem to be a common final pathway of various pathogenetic mechanisms due to different etiologies rather than a disease entity by itself.

6 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Esta é a primeira parte de uma revisão da literatura do sistema visual sensorial. O autor seleciona artigos publicados na literatura entre os anos de 1997 e 1999 relacionados a testes neuro-oftalmológicos, anatomia do nervo óptico, neuropatia óptica isquêmica anterior não arterítica (epidemiologia, etiopatogênese, quadro clínico, tratamento e profilaxia), neuropatia óptica isquêmica anterior arterítica, neuropatia óptica isquêmica posterior, complicações neuro-oftalmológicas das doenças da carótida, neurite óptica desmielinizante, relação entre neurite óptica desmielinizante e esclerose múltipla, neuromielite óptica, neurite óptica auto-imune e neurites ópticas infecciosas. Os artigos são apresentados e comentados quanto às suas conclusões, alcance e relações com o conhecimento previamente estabelecido.
    Arquivos Brasileiros de Oftalmologia 01/2002; 65(1):118-136. DOI:10.1590/S0004-27492002000100024 · 0.42 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To report bilateral optic disk edema and blindness as the unusual initial presentation of acute lymphocytic leukemia (ALL) in an adult. A 19-year-old man presented with a history of headaches, back pain, and 10 days of worsening vision that progressed to blindness. Ocular examination revealed light perception acuity in the right eye and no light perception in the left eye. Fundus examination revealed bilateral profound optic disk edema, tortuous vessels, and retinal hemorrhages. Acute lymphocytic leukemia was diagnosed with complete blood count and bone marrow biopsy. Head computed tomography and magnetic resonance imaging, were normal. Lumbar puncture revealed normal opening pressure. Ocular ultrasonography showed bilateral optic nerve enlargement. Interventional case report and literature review. ESULTS: The presumptive diagnosis of leukemic infiltration of the optic nerves was made, and urgent radiotherapy, intrathecal methotrexate, and intravenous daunorubicin were instituted. Visual acuity improved to hand motions in the right eye. Acute lymphocytic leukemia can rarely present in adults as visual changes due to leukemic optic nerve infiltration. Radiation treatment should be considered as an urgent treatment modality for this rare condition.
    American Journal of Ophthalmology 08/2002; 134(1):141-2. DOI:10.1016/S0002-9394(02)01465-4 · 3.87 Impact Factor

  • Pediatric Blood & Cancer 07/2005; 45(1):72-3. DOI:10.1002/pbc.20369 · 2.39 Impact Factor
Show more