Article

Pathogenesis of primary biliary cirrhosis: CD95-induced apoptosis at last?

Institute of Pathology, University of Ulm, Germany.
European Journal of Gastroenterology & Hepatology (impact factor: 1.76). 08/1998; 10(7):539-41.
Source: PubMed

ABSTRACT Apoptosis is a basic mechanism involved both in maintaining tissue homeostasis by elimination of senescent or potentially harmful cells and in the regulation of immune responses. If not properly regulated, however, it may lead to serious tissue damage. CD95(Fas/APO-1) is a surface receptor that mediates apoptosis upon oligomerization by its ligand, CD95L. The CD95/CD95L-system is one of the major effectors of cytotoxicity in inflammation with implications for both the prevention and the pathogenesis of autoimmune diseases. In primary biliary cirrhosis (PBC), an autoimmune disease, apoptosis has been repeatedly suspected to be the mechanism leading to progressive destruction of bile ducts. The role of apoptosis and its possible molecular inducers in PBC are discussed.

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Keywords

basic mechanism
 
harmful cells
 
immune responses
 
implications
 
inflammation
 
ligand
 
major effectors
 
pathogenesis
 
possible molecular inducers
 
primary biliary cirrhosis
 
progressive destruction
 
serious tissue damage
 
surface receptor
 
tissue homeostasis
 

J Sträter