Leflunomide effectively treats naturally occurring immune-mediated and inflammatory diseases of dogs that are unresponsive to conventional therapy

Stanford University, Palo Alto, California, United States
Transplantation Proceedings (Impact Factor: 0.98). 01/1999; 30(8):4143-8. DOI: 10.1016/S0041-1345(98)01373-6
Source: PubMed
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    • "It has made it possible to transplant dogs, which are notorious for the violence of their rejection responses, even with prednisone and cyclosporine A treatment (Lirtzman et al., 1996). Leflunomide has also shown great promise in the treatment of immune diseases in dogs (Gregory et al., 1998). One of the metabolites of Leflunomide, trifluromethylaniline (TFMA), is highly gastroenterotoxic for dogs. "
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