Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects.

Department of Chemistry, Barry University, Miami Shores, Florida, USA.
Amino Acids (Impact Factor: 3.65). 09/1998; 15(3):263-9. DOI: 10.1007/BF01318865
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ABSTRACT Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.

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