Cocaine, smoking, and spontaneous abortion

New England Journal of Medicine (Impact Factor: 54.42). 03/1999; 340(5):380-1. DOI: 10.1056/NEJM199902043400509
Source: PubMed
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    Anesthesiology 01/2005; 103(4). · 6.17 Impact Factor
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    ABSTRACT: Cocaine is a naturally occurring alkaloid that increases dopamine concentrations in the reward centers of the brain. There has been a marked increase in cocaine abuse over the last two decades. A neuropsychological stimulant, cocaine also reduces somnolence, increases alertness and improves concentration. However, cocaine abuse has many pathophysiological consequences. These fall broadly into four groups: pathology associated with a drug abusing lifestyle, pathology that occurs whilst intoxicated with (but not directly due to) the drug, pathology associated with drug administration and pathology resulting from pharmacological action of the drug. This review provides a detailed description of the physiological, pharmacological, and pathological effects of cocaine, and highlights the forensic and medicolegal implications of cocaine abuse.
    Journal of Clinical Forensic Medicine 04/2003; 10(1):27-39. DOI:10.1016/S1353-1131(03)00003-8
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    ABSTRACT: Illicit substance abuse is more prevalent than thought in women of a child bearing age and its incidence is increasing. Although maternal factors, such as poor socioeconomic status, diet, smoking, alcohol and infection, have detrimental effects on the fetuses of drug-abusing mothers, harm is increased due to the pharmacological activity of the drugs themselves. This article reviews the pharmacophysiological interactions between mother and fetus, describes the general effects of substance abuse during each trimester and details the deleterious effects on the fetus of the more commonly abused controlled drugs.
    Journal of Clinical Forensic Medicine 10/2001; 8(3):129-39. DOI:10.1054/jcfm.2001.0496