Cocaine, smoking, and spontaneous abortion.

New England Journal of Medicine (Impact Factor: 54.42). 03/1999; 340(5):380-1. DOI: 10.1056/NEJM199902043400509
Source: PubMed
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    ABSTRACT: To determine risk factors for miscarriage. A case control study was carried out at the gynaecological wards and antenatal clinics of the De Soysa Maternity Hospital in Sri Lanka. A case was defined as that of mothers with a confirmed diagnosis of partial or full expulsion of the fetus during the first 28 weeks of gestation. Controls comprised ante-natal clinic attendees whose period of gestation was <28 weeks and carrying a viable fetus. Two hundred and thirty cases and 504 controls were selected. A pre-tested interviewer-administered questionnaire and modified life events inventory were used to gather data. Multivariate logistic regression was applied separately for first and second trimester miscarriages and the results were expressed as odds ratios (OR) and as 95% confidence intervals (95% CI). Sleeping < or =8 h/day (OR:3.80, 95% CI:1.01-14.3) was found to be a risk factor for first trimester miscarriage controlling for the effect of period of gestation. Sleeping < or =8 h/day (OR:2.04, 95% CI:1.24-3.37), standing < or =3 h/day (OR:1.83, 95% CI:1.08-3.10), exposure to cooking smoke (OR:3.83, 95% CI:1.50-9.90) and physical trauma during the pregnancy (OR:43.2, 95% CI:4.55-411.4) were found to be risk factors for second trimester miscarriage controlling for the effect of period of gestation. Sleep deprivation, a sedentary lifestyle, exposure to cooking smoke and physical trauma during pregnancy were risk factors for miscarriage. Most of the risk factors are therefore modifiable.
    Australian and New Zealand Journal of Obstetrics and Gynaecology 08/2010; 50(4):352-7. · 1.30 Impact Factor
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    ABSTRACT: Illicit substance abuse is more prevalent than thought in women of a child bearing age and its incidence is increasing. Although maternal factors, such as poor socioeconomic status, diet, smoking, alcohol and infection, have detrimental effects on the fetuses of drug-abusing mothers, harm is increased due to the pharmacological activity of the drugs themselves. This article reviews the pharmacophysiological interactions between mother and fetus, describes the general effects of substance abuse during each trimester and details the deleterious effects on the fetus of the more commonly abused controlled drugs.
    Journal of Clinical Forensic Medicine 10/2001; 8(3):129-39.
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