Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202

Department of Tumor Biology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Oncogene (Impact Factor: 8.46). 02/1999; 18(3):807-11. DOI: 10.1038/sj.onc.1202369
Source: PubMed

ABSTRACT Interferons (IFNs) can exert cytostatic and immunomodulatory effects on carcinoma cells. In particular, growth inhibition of human prostate carcinoma by IFNs has been demonstrated both in vitro and in vivo. p202 is a 52 kd nuclear phosphoprotein known to be induced by IFNs. In this report, we showed that the expression of p202 was associated with an anti-proliferative effect on human prostate cancer cells. More importantly, cells that expressed p202 showed reduced ability to grow in soft-agar, indicating a loss of transformation phenotype. Our data suggest that p202 is a growth inhibitor gene in prostate cancer cells and its expression may also suppress transformation phenotype of prostate cancer cells.

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Available from: Divaker Choubey, Nov 03, 2014
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    • "This domain is associated with apoptosis and interferon response, and has been suggested to be important for p200 protein dimerization. The functions of the p200 family members appear to be distinct from one another in that certain family members, IFI-16, p202, p204, have been clearly shown to have anti-proliferative effects, while others have not: p203, MNDA [6] [7] [8]. In addition, AIM2, was described as a potential tumor suppressor gene in melanoma, is able to inhibit murine fibroblast growth, and enhance susceptibility to apoptosis under reduced serum conditions [9]. "
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