Clinical evaluation of commercially available urinary acidification diets in the management of idiopathic cystitis in cats

Waltham Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, Leicestershire, UK.
Journal of the American Veterinary Medical Association (Impact Factor: 1.56). 03/1999; 214(3):361-5.
Source: PubMed


To compare recurrence of signs of lower urinary tract disease (LUTD) in cats with idiopathic cystitis that were fed the dry or canned formulation of a commercial diet designed to result in production of an acidic urine.
Prospective trial.
54 client-owned cats with idiopathic cystitis that was diagnosed on the basis of a history of abnormal micturition, abnormal results on urinalysis, radiography, or cystoscopy, and lack of an alternative diagnosis.
Cats were assigned to be fed the canned or dry formulation of the diet. Reevaluations conducted at 2 and 16 weeks, and at 6 and 12 months included a physical examination, CBC and serum biochemical analysis (except week 2), blood gas analysis, and urinalysis. Regular telephone contacts were also made. The study was discontinued after 12 months or if signs of LUTD recurred.
Signs of LUTD did not recur in 16 of 18 cats fed the canned diet, and 17 of 28 cats fed the dry diet (chi 2, P < 0.05). Seven cats were reevaluated at recurrence. Owners of remaining cats in which signs of LUTD recurred declined to have their pets reexamined. A different problem (bacterial urinary tract infection) was identified in only 1 cat on reevaluation. Eight cats were lost to follow-up evaluation.
Feeding this commercial canned urinary acidifying diet may reduce the proportion of cats with idiopathic cystitis that will have recurrence of signs of LUTD within a 12-month period.

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    • "tions should be treated when necessary , including urinary tract obstruction , urinary tract infections , and urolith dissolution . In many cases , especially with FIC , individual episodes of LUTS are self - limiting . However , rate of LUTS recurrence within 1 yr can be as great as 40 to 50% in some feline populations ( Barsanti et al . , 1982 ; Markwell et al . , 1999 ) . The objective of this review is to discuss common medical conditions contributing to LUTS and to present currently used and potential preventative dietary modifications ."
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    ABSTRACT: Experimental and clinical investigations have confirmed the importance of dietary modifications in medical protocols designed to treat and prevent feline lower urinary tract signs (LUTS). The objective of this review is to discuss common medical conditions contributing to feline LUTS, and to present currently utilized and potential preventative dietary modifications. Feline LUTS are a set of clinical conditions with similar symptoms related to inappropriate urine elimination due to a combination of genetics, stress and frustration reactions, environment, and medical condition(s) (e.g., idiopathic cystitis, urolithiasis, urethral obstruction, and urinary tract infection). The main goals of dietary modifications to prevent LUTS are: 1) promote large dilute volumes of urine; 2) decrease the relative supersaturation of urine for specific stone types; and 3) promote healthy bacterial populations in the gastrointestinal and urogenital tracts. The impact of dietary composition, including dietary moisture, protein concentration and digestibility, mineral concentrations (i.e., Na, Cl, Ca, P, and Mg), inclusion of acidifiers and alkalinizing agents, inclusion of vitamin B6, EPA, DHA, gamma-linolenic acid, fiber concentration and characteristics, and oxalate degrading probiotics, on these outcomes is discussed, and dietary guidelines for cats are provided. Because of the complex interaction of diet composition, environment, and animal physiology, there is a need for clinical research linking current recommendations or dietary options for the treatment and prevention of LUTS with physiological outcomes (i.e., decreased RSS and LUTS recurrence). Additionally, for many recommendations (e.g., probiotic administration, EPA, DHA), extrapolation from other species was necessary. Research is needed in feline patients with LUTS on these dietary components.
    Journal of Animal Science 02/2013; 91(6). DOI:10.2527/jas.2012-6035 · 2.11 Impact Factor
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    • "No significant difference was seen between treated and untreated cats. The recurrence rate in cats receiving a diet in canned form was lower than in cats receiving the same diet in dry form (Markwell et al 1999). Furthermore improvement of clinical signs in cats with idiopathic cystitis was attributed to the change on a canned diet in one study (Gunn-­‐Moore et al 2004). "
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    ABSTRACT: Idiopathic cystitis and urinary tract infections are diseases of cats included in the term feline lower urinary tract disease. While urinary tract infection is well defined, mostly diagnosable and can often be cured with adequate treatment, idiopathic cystitis remains an unclear syndrome. Idiopathic cystitis is diagnosed by exclusion and no treatment has consistently been successful in against this disease.
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    • "The role of a canned diet in managing cats with idiopathic cystitis has been evaluated in two studies. In one nonrandomized prospective study of cats with idiopathic cystitis, recurrence of clinical signs occurred in 11% of cats consuming a canned food when compared with 39% of cats consuming a dry food [9]. "
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    ABSTRACT: Lower urinary tract disease occurs commonly in cats and is often associated with crystal-related disease. Dietary modification is beneficial in managing some of these diseases, including idiopathic cystitis, urolithiasis, and urethral matrix-crystalline plugs. Altering dietary formulation may result in decreasing urinary concentrations of crystallogenic compounds, increasing urinary concentrations fo crystallogenic inhibitors, and diluting urine composition.
    Veterinary Clinics of North America Small Animal Practice 12/2006; 36(6):1361-76, viii. DOI:10.1016/j.cvsm.2006.08.006 · 0.82 Impact Factor
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