Article

Cognitive-behavioral therapy helps prevent relapse and recurrence of panic disorder following alprazolam discontinuation: A long-term follow-up of the Peoria and Dartmouth studies.

Department of Psychiatry and Behavioral Medicine, University of Illinois College of Medicine at Peoria 61614, USA.
Journal of Consulting and Clinical Psychology (Impact Factor: 4.85). 03/1999; 67(1):151-6. DOI: 10.1037/0022-006X.67.1.151
Source: PubMed

ABSTRACT The present research evaluated patients from 2 previous studies (1 conducted in Peoria, the other at Dartmouth) during a 2- to 5-year posttreatment period. Results showed that 75% of the Peoria sample and 76% of the Dartmouth sample were able to discontinue alprazolam therapy, remain abstinent of any type of treatment for panic disorder, and maintain their acute-treatment clinical gains over this follow-up period. The degree to which patients' anxiety sensitivity declined during treatment predicted relapse versus survival during the 1st 6 months of follow-up, when most relapses occurred. Implications of these findings for benzodiazepine discontinuation, combined pharmacotherapy and psychotherapy, and relapse prevention in panic disorder are discussed.

Download full-text

Full-text

Available from: Timothy J Bruce, Aug 25, 2014
0 Followers
 · 
62 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: State dependent learning (SDL) occurs when learning acquired in one context is not retrievable in a different context. Although traditionally SDL is thought of in the context of substance use, the role of SDL should be considered during combined medication and exposure treatment for anxiety disorders. Data are presented from a within-subjects, case-series design of four participants with social anxiety disorder. Participants engaged in a series of situational exposures while taking either alprazolam (0.75mg), propranolol (40mg), placebo or no medication. They returned 48h later and engaged in the same situational exposure in an unmedicated state to determine retention of learning following the shift in drug context. Results suggest that SDL effects are possible when combining pharmacotherapy (alprazolam) with exposure therapy. Future research is needed determine the conditions under which SDL is most likely to occur and ways to facilitate transfer of learning across different contexts.
    Journal of Psychopathology and Behavioral Assessment 01/2008; 30(3):211-219. DOI:10.1007/s10862-007-9061-1 · 1.55 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Se lleva a cabo una revisión de los tratamientos psicológicos empíricamente validados para el Trastorno de Pánico, para ello se atiende a los criterios establecidos por la American Psychological Association (Task Force on Promotion and Dissemination of Psychological Procedures, 1995), teniendo en cuenta las revisiones y las recomendaciones posteriores (Chambles et al., 1996; 1998; Chambles, y Hollon, 1998; Natahn y Gorman, 1998) respecto a las exigencias metodológicas que tienen que tener los trabajos de investigación. Además, se presta atención tanto a los resultados obtenidos respecto al Eje I (eficacia o validez interna) como al Eje II (efectividad, validez externa o utilidad clínica) de la Guía (Template for Developing Guidelines: Interventions for Mental Disorders and Psychosocial Aspects of Physical Disorders) elaborada por este mismo organismo para desarrollar las directrices prácticas que puedan guiar las intervenciones. Por tanto, se analiza la evidencia empírica disponible sobre este tema con la meta de estudiar la eficacia de cualquier intervención dada y analizar la aplicabilidad y posibilidad de la intervención en el contexto concreto en el que tenga que ofrecerse
    Psicothema 01/2001; 13(3):465-478. · 0.96 Impact Factor
  • Source

Similar Publications