Jacobsen BK, Knutsen SF, Fraser GEDoes high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 9: 553-557
ABSTRACT Recent experimental studies have suggested that isoflavones (such as genistein and daidzein) found in some soy products may reduce the risk of cancer. The purpose of this study was to evaluate the relationship between soy milk, a beverage containing isoflavones, and prostate cancer incidence.
A prospective study with 225 incident cases of prostate cancer in 12,395 California Seventh-Day Adventist men who in 1976 stated how often they drank soy milk.
Frequent consumption (more than once a day) of soy milk was associated with 70 per cent reduction of the risk of prostate cancer (relative risk = 0.3, 95 percent confidence interval 0.1-1.0, p-value for linear trend = 0.03). The association was upheld when extensive adjustments were performed.
Our study suggests that men with high consumption of soy milk are at reduced risk of prostate cancer. Possible associations between soy bean products, isoflavones and prostate cancer risk should be further investigated.
- SourceAvailable from: Ester Pagano
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- "Several studies have shown that isoflavones have effects on glandular epithelium (involving 5-α-reductase inhibition and uridine 5-diphospho-glucuronsyltransferase activation) and on stromal cell in the prostate (including 17-phydroxysteroid dehydrogenase inhibition, aromatase inhibition, and estrogen receptor antagonism); therefore, it may mimic the action of estrogen and may help to detoxify DHT, which fosters prostate tissue proliferation. However, there are no official recommendation for soy products to promote prostate health, but some epidemiological studies link a low incidence of BPH with a diet rich in isoflavones (Morton et al., 1997), and one study shows that a high consumption of soy milk reduces the risk of BPH (Jacobsen et al., 1998). "
ABSTRACT: Benign prostate hyperplasia (BPH) is a common condition affecting older men, with an incidence that is age-dependent. Histological BPH, which typically develops after the age of 40 years, ranges in prevalence from >50% at 60 years to as high as 90% by 85 years of age. Typical symptoms include increased frequency of urination, nocturia, urgency, hesitancy, and weak urine stream. Conventional medicines used for the treatment of BPH include alpha blockers and 5-alpha reductase inhibitors. This articles review the mode of action, the efficacy, and the safety, including herb-drug interactions of the most common botanicals (Serenoa repens, Pygeum africanum, Urtica dioica, and Cucurbita pepo) and nutraceuticals (isoflavones, lycopene, selenium, and β-Sitosterol) in controlling the lower urinary tract symptoms associated to BPH. Copyright © 2013 John Wiley & Sons, Ltd.Phytotherapy Research 07/2014; 28(7). DOI:10.1002/ptr.5084 · 2.40 Impact Factor
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- "Soyfoods and soybean products contain high levels of isoflavones, which have been classified to be a main group of phytoestrogens. Evidences provided in epidemiological studies support that isoflavones such as daidzein and genistein found in soybeans and soy products are protective against breast cancer and prostate cancer (Severson et al. 1989; Jacobsen et al. 1998; Magee and Rowland 2004; Sakamoto et al. 2010; Andres et al. 2011). In Asian countries, especially in Japan, women and men taking Japanese traditional diet, such as consumption of tofu, miso soup, and natto, have low mortality with breast cancer (Smith 1956; Dunn 1975; Nomura et al. 1978) and prostate cancer (Breslow et al. 1977). "
ABSTRACT: Soybean products (soyfoods), reported as potential functional foods, are implicated in several health-enhancing properties, such as easing the symptoms of postmenopausal women, reducing the risk of osteoporosis, preventing cardiovascular disease, and antimutagenic effects. Isoflavone, for example, is one of the most important compounds abundantly found in soybean, mainly accounting for the health-enhancing properties as mentioned earlier. However, most biological activities of isoflavones are mainly attributed to their aglycone forms. It has also been demonstrated that isoflavone aglycones are absorbed faster and in greater amount than their glycosides in human intestines. Fortunately, deglycosylation of isoflavones can be achieved during fermentation process by several strains such as lactic acid bacteria, basidiomycetes, filamentous fungus, and Bacillus subtilis with their β-glucosidase activity. This article presents an overview of soybean's chemistry, application, state-of-the-art advances in soybean fermentation processing and products as well as their applications in food and pharmaceutical industries. Different compounds, such as isoflavone, dietary fibers, and proteins which exhibit significant bioactivities, are summarized. The roles of different microorganisms in bioconversion and enhancement of bioactivities of fermented soybean are also discussed.Applied Microbiology and Biotechnology 08/2012; 96(1):9-22. DOI:10.1007/s00253-012-4330-7 · 3.81 Impact Factor
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- "In a previous study, it has been shown that treatment of prostate cancer cells with the HDAC inhibitor TSA induces cell cycle arrest but not apoptosis (Roy et al, 2005). Epidemiologic evidence suggests that intake of a soy-rich diet may have a protective effect against prostate cancer (Hebert et al, 1998; Jacobsen et al, 1998). Genistein, one of the principal soy isoflavones, shows a wide array of chemopreventive actions. "
ABSTRACT: Background: MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in numerous cellular processes. Recent studies have shown aberrant expression of miRNAs in prostate cancer tissues and cell lines. On the basis of miRNA microarray data, we found that miR-145 is significantly downregulated in prostate cancer. Methods and results: We investigated the expression and functional significance of miR-145 in prostate cancer. The expression of miR-145 was low in all the prostate cell lines tested (PC3, LNCaP and DU145) compared with the normal cell line, PWR-1E, and in cancerous regions of human prostate tissue when compared with the matched adjacent normal. Overexpression of miR-145 in PC3-transfected cells resulted in increased apoptosis and an increase in cells in the G2/M phase, as detected by flow cytometry. Investigation of the mechanisms of inactivation of miR-145 through epigenetic pathways revealed significant DNA methylation of the miR-145 promoter region in prostate cancer cell lines. Microarray analyses of miR-145-overexpressing PC3 cells showed upregulation of the pro-apoptotic gene TNFSF10, which was confirmed by real-time PCR and western analysis. Conclusion: One of the genes significantly upregulated by miR-145 overexpression is the proapoptotic gene TNFSF10. Therefore, modulation of miR-145 may be an important therapeutic approach for the management of prostate cancer.British Journal of Cancer 03/2011; 104(5):892. DOI:10.1038/bjc.2011.71 · 4.82 Impact Factor