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Jacobsen BK, Knutsen SF, Fraser GEDoes high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 9: 553-557

Institute of Community Medicine, University of Tromsø, Norway.
Cancer Causes and Control (Impact Factor: 2.96). 01/1999; 9(6):553-7. DOI: 10.1023/A:1008819500080
Source: PubMed

ABSTRACT Recent experimental studies have suggested that isoflavones (such as genistein and daidzein) found in some soy products may reduce the risk of cancer. The purpose of this study was to evaluate the relationship between soy milk, a beverage containing isoflavones, and prostate cancer incidence.
A prospective study with 225 incident cases of prostate cancer in 12,395 California Seventh-Day Adventist men who in 1976 stated how often they drank soy milk.
Frequent consumption (more than once a day) of soy milk was associated with 70 per cent reduction of the risk of prostate cancer (relative risk = 0.3, 95 percent confidence interval 0.1-1.0, p-value for linear trend = 0.03). The association was upheld when extensive adjustments were performed.
Our study suggests that men with high consumption of soy milk are at reduced risk of prostate cancer. Possible associations between soy bean products, isoflavones and prostate cancer risk should be further investigated.

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    • "Several studies have shown that isoflavones have effects on glandular epithelium (involving 5-α-reductase inhibition and uridine 5-diphospho-glucuronsyltransferase activation) and on stromal cell in the prostate (including 17-phydroxysteroid dehydrogenase inhibition, aromatase inhibition, and estrogen receptor antagonism); therefore, it may mimic the action of estrogen and may help to detoxify DHT, which fosters prostate tissue proliferation. However, there are no official recommendation for soy products to promote prostate health, but some epidemiological studies link a low incidence of BPH with a diet rich in isoflavones (Morton et al., 1997), and one study shows that a high consumption of soy milk reduces the risk of BPH (Jacobsen et al., 1998). "
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    • "Soyfoods and soybean products contain high levels of isoflavones, which have been classified to be a main group of phytoestrogens. Evidences provided in epidemiological studies support that isoflavones such as daidzein and genistein found in soybeans and soy products are protective against breast cancer and prostate cancer (Severson et al. 1989; Jacobsen et al. 1998; Magee and Rowland 2004; Sakamoto et al. 2010; Andres et al. 2011). In Asian countries, especially in Japan, women and men taking Japanese traditional diet, such as consumption of tofu, miso soup, and natto, have low mortality with breast cancer (Smith 1956; Dunn 1975; Nomura et al. 1978) and prostate cancer (Breslow et al. 1977). "
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    • "In a previous study, it has been shown that treatment of prostate cancer cells with the HDAC inhibitor TSA induces cell cycle arrest but not apoptosis (Roy et al, 2005). Epidemiologic evidence suggests that intake of a soy-rich diet may have a protective effect against prostate cancer (Hebert et al, 1998; Jacobsen et al, 1998). Genistein, one of the principal soy isoflavones, shows a wide array of chemopreventive actions. "
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