Survival in air of Mytilus trossulus following long-term exposure to spilled Exxon Valdez crude oil in Prince William Sound.
ABSTRACT Mussels, Mytilus trossulus, were sampled in 1996 from beaches in Prince William Sound (PWS) which contained residual oil resulting from the Exxon Valdez oil spill of March 1989, and from one beach which had been lightly oiled in 1989, but contained no residual oil in 1996. The latter mussels served as un-oiled references. Mussels were also collected from Tee Harbor, Southeast Alaska, to be used as an additional reference group. Where the size of the individuals in the resident population would permit, two size groups were sampled, 32-35 and 18-20 mm in length. Polynuclear aromatic hydrocarbon (PAH) concentrations in mussel tissue, and air survival time were determined for each group of mussels. Total PAH concentrations were significantly greater in tissue of mussels from oiled beds (0.6-2.0 micrograms g-1) than from references (0.01-0.12 microgram g-1) (P < 0.01). Oil-exposed mussels had significantly lower LT50 values (P < 0.05) for air survival than reference groups. Tolerance of small mussels to air exposure was significantly greater (P < 0.01) than large mussels in both the unoiled reference and oil exposed groups.
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ABSTRACT: Prolonged administration of methyl transferase inhibitors may increase response rates in myelodysplastic syndromes (MDS). Fourteen MDS patients with anemia and less than 10% marrow blasts received azacitidine 50 mg/m(2) thrice weekly for 2 weeks every 4 weeks; 7 also received weekly erythropoietin. The response rate of 43% did not improve the rates reported with other azacitidine administration schedules, so the study was closed. A decreased apoptosis of primitive erythroid progenitors and increased expression of BclX(L) was observed with treatment in responding patients compared to non-responders. Azacitidine may modulate BclX(L) and improve erythropoiesis through reduction of apoptosis in primitive erythroid progenitor population in MDS.Leukemia research 03/2011; 35(8):1108-10. · 2.36 Impact Factor
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ABSTRACT: Cypermethrin is a pyrethroid pesticide widely used to combat agricultural pests. However, little information is available about its toxicity in aquatic macroinvertebrates in the context of the Moroccan coastline. In this study, a suite of physiological and behavioral biomarkers for water quality surveillance using mussels are used to characterize the toxicity of Cypermethrin. In these tests, sublethal effects on valve activity behavior, byssal thread formation, and survival in air of the mussel Mytilus galloprovincialis were assessed in short-term exposure. The results show that Cypermethrin impaired the valve activity in a concentration-dependent manner, leading to a reduction in the time of normal opening. The lowest effect concentration was determined as 100 μg/l Cypermethrin. Prolonged closures of mussels were also observed for the exposures to 400 and 800 μg/l. The delay to the first detection of the pesticide was concentration dependent. The capacity to produce new byssus threads in a Cypermethrin exposure was inhibited at all concentrations and especially at high concentrations. Survival in air was not affected even at 800 μg/l Cypermethrin.Archives of Environmental Contamination and Toxicology 04/2011; 60(3):462-70. · 2.01 Impact Factor
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ABSTRACT: Despite a large number of gas platforms existing in the Adriatic Sea, which is a semi-enclosed basin characterized by a slow turnover rate and increasing industrial as well as other anthropogenic activities, the effects of these structures on the aquatic ecosystem require further investigation. Since 1998, multidisciplinary studies have been performed by CNR-ISMAR to comply with legislation and to support the development of protocols for the monitoring of offshore activities in the Adriatic Sea. The present study was developed to implement a biomonitoring plan to assess the ecotoxicological effects of the extraction activities of an off-shore gas platform. Biomarkers were evaluated in mussels collected from the platform in relation to physiological stress, DNA damage, cellular damage, oxidative stress and exposure effects. Organic contaminants and trace element bioaccumulation were also assessed in the soft body of the mussels to correlate bioaccumulation of pollutants with biomarker responses. The results indicate an absence of platform-related environmental stress.Marine pollution bulletin 09/2011; 62(11):2483-95. · 2.63 Impact Factor