Segmented k-space fast cardiac imaging using an echo-train readout.
ABSTRACT A segmented k-space fast gradient-echo pulse sequence with an echo-train readout (FGRE-ET) was developed for high-quality cine imaging of the heart in reduced scan times. Using segmented FGRE-ET, cine images of the heart can be acquired in as few as 1-5 heart beats and do not display the geometric distortion and flow-related artifacts typically associated with cardiac echoplanar imaging (EPI). Segmented FGRE-ET was compared with conventional segmented FGRE and with conventional multi-phase EPI in normal volunteers. Segmented FGRE-ET was found to have reduced temporal blurring compared with segmented FGRE for cine imaging in 4 heart beats (P<0.05). Also, segmented FGRE-ET did not display geometric distortion characteristic of conventional EPI (P<0.05). Segmented FGRE-ET may be particularly applicable to functional cardiac stress testing because it allows versatile cine imaging in very short breath-holds.
Article: Improved cine displacement-encoded MRI using balanced steady-state free precession and time-adaptive sensitivity encoding parallel imaging at 3 T.[show abstract] [hide abstract]
ABSTRACT: Cine displacement-encoded MRI is a promising modality for quantifying regional myocardial function. However, it has two major limitations: low signal-to-noise ratio (SNR) and data acquisition efficiency. The purpose of this study was to incrementally improve the SNR and the data acquisition efficiency of cine displacement-encoded MRI through the combined use of balanced steady-state free precession (b-SSFP) imaging, 3T imaging, echo-combination image reconstruction, and time-adaptive sensitivity encoding (TSENSE) parallel imaging. Phantom experiments were performed to empirically determine the optimal excitation angle (alpha) and to estimate the measurement errors in the presence of 130 Hz peak-to-peak static magnetic field (B0) variation. The optimal alpha was determined to be 20 degrees . The intrinsic phase correction in the echo-combination effectively reduced the phase error, which produced small displacement errors (0.11 versus 0.11 mm) and negligible strain errors (-0.001 versus -0.002). Six healthy volunteers were imaged in three short-axis levels of the heart to evaluate the SNR and the relative accuracy of strain calculations. Compared with the 24-heartbeat cine echo-planar imaging acquisition, the 24-heartbeat non-accelerated b-SSFP acquisition yielded approximately 65% higher SNR, and the 12-heartbeat twofold accelerated b-SSFP acquisition yielded approximately 28% higher SNR. The 12-heartbeat twofold accelerated b-SSFP acquisition yielded functional maps with spatial resolution of 3.6 x 3.6 mm, temporal resolution of 35 ms, and relatively high SNR (31.2 +/- 5.4 at end diastole; 19.9 +/- 3.6 at end systole; 10.3 +/- 1.1 at late diastole; mean +/- SD). The left ventricular strain values between the non-accelerated and twofold accelerated b-SSFP acquisitions correlated strongly (slope = 0.99; bias = 0.00; R2 = 0.91) and were in excellent agreement. The combined implementation of b-SSFP imaging, 3T imaging, echo-combination image reconstruction, and TSENSE parallel imaging can be used to incrementally improve the cine displacement-encoded MRI pulse sequence.NMR in Biomedicine 11/2007; 20(6):591-601. · 3.21 Impact Factor
Article: Accurate computer-aided quantification of left ventricular parameters: experience in 1555 cardiac magnetic resonance studies from the Framingham Heart Study.[show abstract] [hide abstract]
ABSTRACT: Quantitative analysis of short-axis functional cardiac magnetic resonance images can be performed using automatic contour detection methods. The resulting myocardial contours must be reviewed and possibly corrected, which can be time-consuming, particularly when performed across all cardiac phases. We quantified the impact of manual contour corrections on both analysis time and quantitative measurements obtained from left ventricular short-axis cine images acquired from 1555 participants of the Framingham Heart Study Offspring cohort using computer-aided contour detection methods. The total analysis time for a single case was 7.6 ± 1.7 min for an average of 221 ± 36 myocardial contours per participant. This included 4.8 ± 1.6 min for manual contour correction of 2% of all automatically detected endocardial contours and 8% of all automatically detected epicardial contours. However, the impact of these corrections on global left ventricular parameters was limited, introducing differences of 0.4 ± 4.1 mL for end-diastolic volume, -0.3 ± 2.9 mL for end-systolic volume, 0.7 ± 3.1 mL for stroke volume, and 0.3 ± 1.8% for ejection fraction. We conclude that left ventricular functional parameters can be obtained under 5 min from short-axis functional cardiac magnetic resonance images using automatic contour detection methods. Manual correction more than doubles analysis time, with minimal impact on left ventricular volumes and ejection fraction.Magnetic Resonance in Medicine 10/2011; 67(5):1478-86. · 2.96 Impact Factor
Article: High spatial and temporal resolution cardiac cine MRI from retrospective reconstruction of data acquired in real time using motion correction and resorting.[show abstract] [hide abstract]
ABSTRACT: Cine MRI is used for assessing cardiac function and flow and is typically based on a breath-held, segmented data acquisition. Breath holding is particularly difficult for patients with congestive heart failure or in pediatric cases. Real-time imaging may be used without breath holding or ECG triggering. However, despite the use of rapid imaging sequences and accelerated parallel imaging, real-time imaging typically has compromised spatial and temporal resolution compared with gated, segmented breath-held studies. A new method is proposed that produces a cardiac cine across the full cycle, with both high spatial and temporal resolution from a retrospective reconstruction of data acquired over multiple heartbeats during free breathing. The proposed method was compared with conventional cine images in 10 subjects. The resultant image quality for the proposed method (4.2 +/- 0.4) without breath holding or gating was comparable to the conventional cine (4.4 +/- 0.5) on a five-point scale (P = n.s.). Motion-corrected averaging of real-time acquired cardiac images provides a means of attaining high-quality cine images with many of the benefits of real-time imaging, such as free-breathing acquisition and tolerance to arrhythmias.Magnetic Resonance in Medicine 09/2009; 62(6):1557-64. · 2.96 Impact Factor