Reduction of alcohol induced sleep time in albino mice by potentized Nux vomica prepared with 90% ethanol.
ABSTRACT Male adult albino mice were administered potentized Nux vomica 30 c (Nux v). The drug was mixed with sterile distilled water at 0.05 ml/2 ml water and given at 0.05 ml/individual. Control consisted of blank ethanol solution. Ethanolic extract from the seeds of Strychnos nuxvomica L was mixed with 90% ethanol 1:100 and sonicated for 30 s at 20 KHz. This was further diluted and sonicated in 30 steps to produce Nux v 30 c. Six hours after treatment, mice were given 25% ethanol i.p. at 4 g/kg body wt. The duration of sleep time starting from the loss of righting reflex until its restoration was recorded for each mouse. The duration of sleep time with ethanol was recorded in four sessions for the same group of mice with an interval of 10 d between sessions. Treatments: session 1 with control solution, 2 with Nux v (oral), 3 with control solution and 4 with Nux v (i.p.). Nux v (oral) produced the shortest sleep time as compared to other treatments which did not differ from each other significantly with respect to sleep time. In another experiment Nux v 30 c was prepared with distilled water and pure absolute ethanol by the above process of successive dilution and sonication. These two preparations together with Nux v 30 c, prepared with 90% ethanol, were tested on mice for their effect on alcohol-induced sleep time. Only Nux v 30 c prepared with 90% ethanol was effective in reducing the sleep time in mice. It is concluded that the solution structure of ethanol/water mixture carries the specificity of the Nux v at ultra high dilution. It is further concluded that the effect is mediated through oral receptors.
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The Journal of Alternative and Complementary Medicine 11/2005; 11(5):763-9. DOI:10.1089/acm.2005.11.763 · 1.52 Impact Factor
- "Homeopathically-prepared glutamate has protective effects for rat neurons in cell culture when used isopathically for experimental glutamate toxicity (Jonas et al. 2001). Sleep electroencephalographic patterns of animals differ from controls after ingestion of one of two different homeopathically-prepared remedies, i.e., coffea cruda (Ruiz-Vega et al. 2000) and nux vomica (Ruiz 1997; Sukul et al. 1999), that are reported to exert effects on human sleep in clinical settings. Cataleptic effects of haloperidol increase as a function of concomitant treatment with ultra dilutions of various homeopathically-prepared remedies in animals (Sukul 1986). "
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ABSTRACT: In the U.S., large-scale national surveys have shown that the percentage of adults reporting use of homeopathy in the past 12 months has grown from 0.7% in 1990 to 3.4% in 1997 (Eisenberg, 1998), with continued annual growth. Reasons for trying homeopathy among users from the CDC-based report from the 2002 National Health Interview Survey (Barnes, Powell-Griner, McFann, & Nahin, 2004) included 43% expecting the combination of conventional and homeopathic treatment would help; 36.7% indicating that conventional medical treatments would not help their condition; and 19.4% stating that conventional medical treatments were too expensive. Consumers use homeopathy both for self-care and under practitioner supervision. In homeopathy, the mental, emotional, and/or physical symptoms that a patient presents lead to selection of a medicine (remedy) to treat the patient as a whole. Homeopathic medicines are manufactured from natural animal, mineral, and plant sources. The source material is crushed in lactose and/or extracted and dissolved in a water-alcohol solvent. Remedy preparation involves serial dilution and succussion (vigorous shaking) of the source material, commonly by factors of 10 (decimal series, X) or 100 (centesimal series, c) to 1 in distilled water. Thus, a 12X remedy has been diluted (1/10)12 and succussed 240 (or more) times. The final remedy is often stabilized by addition of small amounts of pharmaceutical-grade ethanol and formulated in dissolvable pellets or tablets containing lactose and/or sucrose for ease of oral administration. Unlike many dietary supplements such as herbs, the preparation of homeopathic remedies is standardized in published monographs from the Homeopathic Pharmacopoeia of the U.S. (see Legal/Regulatory Status below). Consumers use single or mixtures of homeopathic over-the-counter remedies for self-care first aid in injuries (Oberbaum, Schreiber, Rosenthal, & Itzchaki, 2003) or acute illnesses such as colds and flu (Vickers, 2006). Many times the remedies appear to shorten the duration of the acute illness or speed up the recovery process. For treatment of many persons with a wide range of chronic symptoms, constitutional homeopathic treatment involves a highly trained and experienced practitioner to select the correct treatment with a single remedy at a time and manage the case in partnership with the patient over a period of months to years. However, many consumers manage their own intercurrent symptoms using over-the-counter remedies as part of their self-care.