Bacitracin versus mupirocin for Staphylococcus aureus nasal colonization.

Department of Medicine, Maimonides Medical Center, Brooklyn, New York 11219, USA.
Infection Control and Hospital Epidemiology (Impact Factor: 3.94). 06/1999; 20(5):351-3. DOI: 10.1086/501633
Source: PubMed

ABSTRACT We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S. aureus. After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P = .0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of S. aureus in healthy HCWs.

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