"Following the discovery of estrogens in 1929 (Butenandt, 1929), research on this class of steroid hormones focused on their role in reproduction and the menstrual/estrous cycle in females (Doisy, 1972). In 1966, an ER was characterized in breast and uterine tissue (Toft and Gorski, 1966), and this ER was also localized to brain regions typically associated with endocrine or reproductive functions, such as the hypothalamus (for review see McEwen and Alves, 1999). This receptor, now known as ERα, was observed primarily in cell nuclei, typical for steroid hormone receptors. "
Hormones and Behavior 06/2015; 74. DOI:10.1016/j.yhbeh.2015.06.010 · 4.63 Impact Factor
"There is also the possibility that estrogen, as opposed to testosterone, regulates antisocial behavior, given that testosterone is readily aromatized into estrogen. Estradiol is capable of inducing neural and behavioral effects via nongenomic mechanisms (McEwen & Alves, 1999). Studies are needed to understand the neural mechanism underlying the effects for testosterone variability and moderated effects. "
[Show abstract][Hide abstract] ABSTRACT: The purpose of this report is to provide evidence of an association between within-person variability in diurnal testosterone over 1 year, lifetime exposure to violence, and the manifestation of antisocial behavior in 135 pubertal-aged adolescents across 1 year. Adolescents' sex and lifetime history of violence exposure moderated the association between within-person variability in diurnal testosterone and antisocial behavior. Furthermore, sex-stratified analyses revealed that lifetime history of exposure to violence moderated the association between within-person variability in diurnal testosterone and antisocial behavior in females only. This report is unique in that it illuminates sex differences in within-person associations among exposure to violence, individual variability in diurnal testosterone, and antisocial behavior.
Development and Psychopathology 01/2015; -1(4pt1). DOI:10.1017/S095457941400145X · 4.89 Impact Factor
"Neural mechanisms for chronic and acute effects of estrogens Background Ample evidence exists that estrogens cause morphologic and neurochemical changes in many areas of the brain when given acutely or chronically to animals or humans. Chronic treatments alter the major neuronal systems of the brain including, but not limited to, cholinergic, monoaminergic, GABAergic and glutaminergic neurons in both animals and humans (Gibbs, 2010; McEwen and Alves, 1999 "
[Show abstract][Hide abstract] ABSTRACT: A historical perspective on estradiol’s enhancement of cognitive function is presented, and research, primarily in animals, but also in humans, is reviewed. Data regarding the mechanisms underlying the enhancements are discussed. Newer studies showing rapid effects of estradiol on consolidation of memory through membrane interactions and activation of inter-cellular signaling pathways are reviewed as well as studies focused on traditional genomic mechanisms. Recent demonstrations of intra-neuronal estradiol synthesis and possible actions as a neurosteroid to promote memory are discussed. This information is applied to the critical issue of the current lack of effective hormonal (or other) treatments for cognitive decline associated with menopause and aging. Finally, the critical period hypothesis for estradiol effects is discussed along with novel strategies for hormone/drug development. Overall, the historical record documents that estradiol positively impacts some aspects of cognitive function, but effective therapeutic interventions using this hormone have yet to be realized.
Hormones and Behavior 09/2014; 66(4). DOI:10.1016/j.yhbeh.2014.08.011 · 4.63 Impact Factor
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