Multiple chondromatous hamartomas of the lung: a case report and review of the literature with special reference to Carney syndrome.
ABSTRACT Multiple chondromatous hamartomas of the lung, which are very rare, are a feature of Carney syndrome. The relation between the two entities is not clear.
A patient with multiple chondromatous hamartomas of the lung is described in this article. The literature was reviewed with special reference to the relation between multiple chondromatous hamartomas of the lung and Carney syndrome as well as the triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma.
A total of 15 cases of multiple chondromatous hamartomas of the lung have been published worldwide. Two cases exhibited two other features of Carney syndrome, namely, gastric leiomyogenic neoplasms and extra-adrenal paragangliomas, and three other cases demonstrated only gastric leiomyomatous neoplasms. These five patients were all young females.
Some patients with multiple chondromatous hamartomas of the lung have a history of Carney syndrome. Patients with multiple chondromatous hamartomas require further examination of other sites, particularly the stomach and nervous system.
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ABSTRACT: The clinical and pathological data were reviewed on 17 patients with benign endobronchial mesenchymal tumors seen at the New England Deaconess Hospital between 1942 and 1981. The tumors were compared histologically to 147 intraparenchymal hamartomas studied during the same period. Thirteen tumors involved central bronchi and four occupied small, peripheral airways. These 17 lesions displayed overlapping histological features and ranged from predominantly cartilaginous to lipomatous growths. Mixtures of cartilage and other mesenchymal elements characterized 14 tumors, and adipose tissue was the principal component of three nonchondromatous growths. Both endobronchial and parenchymal tumors occurred predominantly during the fifth and sixth decades. Tumors of both groups contained similar mesenchymal constituents; however, the endobronchial lesions had fewer epithelial clefts, a decreased proportion of cartilage, and a correspondingly increased adipose tissue component. The centrally located intralumenal growths caused symptoms due to bronchial obstruction, while the four tumors within peripheral airways were usually symptomless, incidental findings. The histological similarity between the to groups and the presence of some endobronchial tumors within small, peripheral airways support the theory that endobronchial and parenchymal "hamartomas" are similar mesenchymal neoplasms of bronchial and bronchiolar walls occurring at different loci within the bronchial tree.American Journal of Surgical Pathology 10/1982; 6(6):531-40. · 4.87 Impact Factor
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ABSTRACT: Phantom studies comparing skull radiography and cranial computed tomography (CT) show that CT is 5 to 15 times more sensitive than skull radiography in the detection of intracranial calcifications. The difference in detectability varies with object size. The relative sensitivity of CT increases with increased object size within the constraints of the section thickness. The relationship of these findings to the detectability of pineal and choroid calcifications is discussed.Journal of Computer Assisted Tomography 02/1978; 2(1):61-4. · 1.58 Impact Factor
Article: Pulmonary hamartoma.Archives of pathology 01/1970; 88(6):584-92.