Plant Stanol Esters and Vitamin K

Mayo Clinic Rochester, Rochester, Minn
Mayo Clinic Proceedings (Impact Factor: 6.26). 07/1999; 74(6):642-3. DOI: 10.4065/74.6.642
Source: PubMed
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    ABSTRACT: Diss. -- Kuopion yliopisto.
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    ABSTRACT: Plant sterols and stanols derived from wood pulp and vegetable oils lower total and LDL cholesterol by inhibiting cholesterol absorption from the intestine in humans. Plant stanols are virtually unabsorbable, which makes them more ideal hypocholesterolemic agents than plant sterols. The esterification of plant stanols has allowed their incorporation into various foods such as margarine without changing the taste and texture of those foods. Plant stanol esters at a level of 2-3 g/d have been shown to reduce LDL cholesterol by 10-15% without side effects. Plant stanol esters appear to be a helpful dietary adjunct to a prudent diet to lower cholesterol.
    Journal of Nutrition 01/2000; 129(12):2109-12. · 3.88 Impact Factor
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    ABSTRACT: Plant stanol ester has been shown in over 20 studies to be an effective and safe cholesterol-lowering substance. Randomized, placebo-controlled studies indicate that 2–3 g/day of plant stanol ester significantly reduces low density lipoprotein cholesterol levels by about 10%–20%. These results have been consistently found in various groups, including young adult and elderly men, pre- and postmenopausal women, children with and without familial hypercholesterolemia, type II diabetics, and patients with coronary heart disease. Plant stanol ester has also been shown to significantly augment the cholesterol-lowering effect of statins. No clinically significant adverse effects have been detected in studies or in general use in Finland, where foods fortified with plant stanol ester have been available since 1995. Results of studies with plant stanol ester have important implications for both the clinical and public health approaches to coronary heart disease risk reduction.
    Preventive Cardiology 05/2000; 3(3):121 - 130. DOI:10.1111/j.1520-037X.2000.80370.x
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