Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES)

School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.42). 07/1999; 9(12):1645-50. DOI: 10.1016/S0960-894X(99)00245-0
Source: PubMed


We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

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