Cassatella, M. A. Neutrophil-derived proteins: selling cytokines by the pound. Adv. Immunol. 73, 369-509

Department of Pathology, Faculty of Medicine, University of Verona, Italy.
Advances in Immunology (Impact Factor: 5.53). 02/1999; 73:369-509. DOI: 10.1016/S0065-2776(08)60791-9
Source: PubMed
  • Source
    • "In the past few years, however, this limited view has been challenged and it is now clear that the function of neutrophils cannot be merely explained in terms of phagocytosis, killing and degradation of internalized pathogens [34] [35]. In fact, neutrophils produce a broad array of cytokines and chemokines [36], modulate the function of immune cells such as macrophages, dendritic cells, NK cells, and conventional T cells, and are also able to acquire different functional profiles [37] [38] [39] [40] [41], a matter that has been the subject of many studies in the field of anti-tumor immunity [42]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: γδ T cells have been shown to stimulate the recruitment and activation of neutrophils through the release of a range of cytokines and chemokines. Here, we investigated the reverse relationship, showing that human neutrophils suppress the function of human blood γδ T cells. We show that the upregulation of CD25 and CD69 expression, the production of IFN-γ, and the proliferation of γδ T cells induced by HMBPP are inhibited by neutrophils. Spontaneous activation of γδ T cells in culture is also suppressed by neutrophils. We show that inhibitors of prostaglandin E2 and arginase I do not exert any effect, although in contrast, catalase prevents the suppression of γδ T cells induced by neutrophils, suggesting the participation of neutrophil-derived ROS. We also show that the ROS-generating system xanthine/xanthine oxidase suppresses γδ T cells in a similar fashion to neutrophils, while neutrophils from chronic granulomatous disease patients only weakly inhibit γδ T cells. Our results reveal a bidirectional cross-talk between γδ T cells and neutrophils: while γδ T cells promote the recruitment and the activation of neutrophils to fight invading pathogens, neutrophils in turn suppress the activation of γδ T cells to contribute to the resolution of inflammation. This article is protected by copyright. All rights reserved.
    European Journal of Immunology 03/2014; 44(3). DOI:10.1002/eji.201343664 · 4.52 Impact Factor
  • Source
    • "The pattern of cytokines production by peripheral neutrophils greatly differs depending on the agonist, co-stimulation, and ligands present. The mechanisms of cytokine production are well described (Cassatella, 1999; Witko-Sarsat et al., 2000). The most potent inducers of neutrophils are presented in Table 2. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Neutrophils are one of the main types of effector cells in the innate immune system. Neutrophils play a major role in fighting diseases and are recruited almost immediately to sites of infection. The neutrophils have a variety of defensive mechanisms and their high affinity to chemotactic agents makes them ideal in the defense against pathogens. New functions of neutrophils have been discovered over the years. The latest role of neutrophils is neutrophil traps, which are a new component of innate anti-microbial immunity. Before neutrophils can effectively kill microorganisms they undergo a series of complex developmental processes.
    Respiratory Physiology & Neurobiology 03/2013; 187(1). DOI:10.1016/j.resp.2013.02.023 · 1.97 Impact Factor
  • Source
    • "By contrast, tumor-associated polymorphonuclear neutrophils (TAN) have received less attention, likely because granulocytes have been traditionally viewed as short-lived cells, only playing a crucial role in host defense toward microorganisms for their capacity to release a battery of proteases and bactericidal substances, as well as to generate reactive oxygen species [5]. However, recent studies uncovering the capability of neutrophils to transcribe cytokine-and chemokine-encoding genes [6] have greatly broadened our knowledge on their potential functional role, even in unsuspected pathological processes such as in tumor [7]. Consistently, neutrophils have been often found as components of the inflammatory infiltrate characterizing many models of human and murine cancers [8] in which neutrophilattracting CXC-chemokines [9] and/or pro-survival factors [10] are constitutively produced by tumor and surrounding stroma cells [9] [11]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Although traditionally viewed as short-lived innate immunity cells, only playing a crucial role in host defense toward infections, neutrophils have recently become subject of a new wave of research in diverse research areas including in tumors. Indeed, increasing experimental evidence indicate that neutrophils may directly or indirectly influence the tumor fate through the release of a wide array of molecules able to exert either pro-tumor or anti-tumor functions depending on the microenvironment milieu, including cytokines. This review therefore attempts to uncover the role that neutrophils play during the different steps of tumor development (from promotion to progression), as well as in anti-tumor responses, via cytokine production.
    Seminars in Cancer Biology 02/2013; 23(3). DOI:10.1016/j.semcancer.2013.02.004 · 9.33 Impact Factor
Show more