Biological effects of Myristica fragrans (nutmeg) extract

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Nigeria.
Phytotherapy Research (Impact Factor: 2.66). 06/1999; 13(4):344-5. DOI: 10.1002/(SICI)1099-1573(199906)13:4<344::AID-PTR436>3.0.CO;2-E
Source: PubMed


The chloroform extract of nutmeg has been evaluated for antiinflammatory, analgesic and antithrombotic activities in rodents. The extract inhibited the carrageenan-induced rat paw oedema, produced a reduction in writhings induced by acetic acid in mice and offered protection against thrombosis induced by ADP/adrenaline mixture in mice.

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    • "Nutmeg has been shown to possess analgesic (Sonavane et al. 2001), antifungal (Nadkarni 1998), antimicrobial (Takikawa et al. 2002), antiinflammatory (Olajide et al. 1999), as well as hepatoprotective (Morita et al. 2003) activities in various in vitro and in vivo studies. With regard to its medicinal and commercial value, the dried kernel (seed) and mace/aril are the most exploited parts. "
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    ABSTRACT: A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated from Myristica fragrans for the first time. Apart from these two, previously known steroids, other lignans and neolignans were isolated from the fruit pericarp of M. fragrans. The structures of the compounds were identified by employing various spectroscopic methods.
    Natural Product Research 07/2014; 28(20):1-5. DOI:10.1080/14786419.2014.934236 · 0.92 Impact Factor
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    • "Recent studies indicate that nutmeg is useful against damage caused by gamma radiation and also in the improvement of mouse memory.[67] Anti-inflammatory activity of nutmeg has also been reported in addition to its insulin-like biological activity.[89] Nutmeg has been reported to possess cardio tonic property in the ancient and traditional system of Indian medicine, which prompted us to select the nutmeg aqueous extract (NMAET) to treat hepatotoxicity associated with ISO-induced oxidative stress. "
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    ABSTRACT: Nutmeg a well-known spice used as a folk medicine in India to treat stomach ailments. Worldwide it is commonly used for food preservation and fragrance. Abundant references were given for nutmeg in ayurveda, unani, and siddha as a single drug or as an important constituent in formulations. In the present study, nutmeg aqueous extract (NMAET) was evaluated against isoproterenol (ISO)-induced hepatotoxicity and oxidative stress. Antioxidant enzymes, liver functions tests, and lipid profile tests were performed using standard procedures. Histological examination of liver was done by fixing in formaldehyde solution and hematoxylin staining. Oral administration of NMAET effectively inhibited the ISO-induced changes in the activities of hepatic marker and antioxidant enzymes in plasma and heart tissue along with lipid peroxidation levels. The liver sections of ISO administered rats showed massive fatty changes, necrosis, ballooning degeneration, and broad infiltration of the lymphocytes and the loss of cellular boundaries; these changes were completely absent in groups treated with extract. Analysis of variance and Duncan's Multiple Range tests were used to perform statistical analysis. Results suggest that the NMAET possess significant potential as hepatoprotective and antioxidative agent against ISO-induced damage in rats.
    Journal of Ayurveda and integrative medicine 10/2013; 4(4):216-23. DOI:10.4103/0975-9476.123704
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    • ") . Glycosides are implicated to cause increase in WBC count ( Anthai et al . , 2009 ) because they possess anti - inflammatory properties and have vital effect on inflammatory processes of some pathological states such as bacterial infections , malaria and liver diseases ( Olajide et al . , 1999 ; Ugochukwu , 2002 ; Balasundram et al . , 2006 ) ."
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    ABSTRACT: In spite of wide spread biological uses of Myristica fragrans (nutmeg), there is a dearth of information on its effects on haematological indices. This work was therefore conducted to evaluate the effects of ethanolic extract of M. fragrans on some haematological indices using albino rat as a model. Twenty four (24) Wistar strain albino rats weighing 140 to 160 g were randomly distributed into four (4) groups of six (6) animals per group. Group I consists of rats which received 10 ml/kg normal saline (orally) and served as the control while those in Groups II, III and IV received 50% ethanolic seed extract of M. fragrans (orally) at doses of 100, 250 and 500 mg/kg, respectively. In all groups, the blood samples were obtained by cardiac puncture for analysis of haematological indices after feeding regimens lasted for 14 days. The results showed significant decreases (p< 0.05) in red blood cell (RBC) count, packed cell volume (PCV), haemoglobin concentration (HbC) and platelet count especially at high doses. There was significant increase (p< 0.05) in total white blood cell (WBC) count. This study therefore seems to confirm the anti-inflammatory properties of seed of M. fragrans and also suggests that it may have deleterious effects on haemopoiesis at high doses.
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