Biological effects of Myristica fragrans (nutmeg) extract.
ABSTRACT The chloroform extract of nutmeg has been evaluated for antiinflammatory, analgesic and antithrombotic activities in rodents. The extract inhibited the carrageenan-induced rat paw oedema, produced a reduction in writhings induced by acetic acid in mice and offered protection against thrombosis induced by ADP/adrenaline mixture in mice.
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ABSTRACT: Due to potential liver damage and carcinogenic effects, the most widely used synthetic antioxidant compounds, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), have restricted usage (Senevirathne et al., 2006). Therefore, much emphasis is currently being given to searching for new and natural antioxidants and antimicrobials from dietary plants, because they can safeguard the human body against the oxidative damage of biological macromolecules. Many spices, such as nutmeg (Myristica fragrans), have been reported to have antioxidant and antimicrobial properties, apart from their traditional use in numerous medical conditions, and can thus offer a potential solution in the search for new and natural sources of antioxidants and antimicrobials.Nuts & Seeds in Health and Disease Prevention, 1st edited by V. R. Preedy, R. R. Watson, V. B. Patel, 01/2011: chapter Antioxidant and antimicrobial activity of nutmeg (Myristica fragrans).: pages 831-839; Elsevier Inc.., ISBN: 9780123756886
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ABSTRACT: A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated from Myristica fragrans for the first time. Apart from these two, previously known steroids, other lignans and neolignans were isolated from the fruit pericarp of M. fragrans. The structures of the compounds were identified by employing various spectroscopic methods.Natural Product Research 07/2014; · 1.03 Impact Factor
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ABSTRACT: Nutmeg a well-known spice used as a folk medicine in India to treat stomach ailments. Worldwide it is commonly used for food preservation and fragrance. Abundant references were given for nutmeg in ayurveda, unani, and siddha as a single drug or as an important constituent in formulations. In the present study, nutmeg aqueous extract (NMAET) was evaluated against isoproterenol (ISO)-induced hepatotoxicity and oxidative stress. Antioxidant enzymes, liver functions tests, and lipid profile tests were performed using standard procedures. Histological examination of liver was done by fixing in formaldehyde solution and hematoxylin staining. Oral administration of NMAET effectively inhibited the ISO-induced changes in the activities of hepatic marker and antioxidant enzymes in plasma and heart tissue along with lipid peroxidation levels. The liver sections of ISO administered rats showed massive fatty changes, necrosis, ballooning degeneration, and broad infiltration of the lymphocytes and the loss of cellular boundaries; these changes were completely absent in groups treated with extract. Analysis of variance and Duncan's Multiple Range tests were used to perform statistical analysis. Results suggest that the NMAET possess significant potential as hepatoprotective and antioxidative agent against ISO-induced damage in rats.Journal of Ayurveda and integrative medicine 10/2013; 4(4):216-23.