Article

The human immune response during cutaneous leishmaniasis: NO problem.

Hematology Laboratory, Faculty of Pharmacy Paris V, 4 Avenue de l'Observatoire, 75006 Paris, France.
Parasitology Today 09/1999; 15(8):342-5. DOI:10.1016/S0169-4758(99)01477-5 pp.342-5
Source: PubMed

ABSTRACT During some helminth infections, increased expression of the low-affinity receptor for IgE (CD23/FcepsilonRII) by macrophages and/or increased levels of plasma IgE have been seen, but their role in host protection or disease progression remains unclear. Recently, crosslinking of CD23 was shown to promote intracellular killing of Leishmania parasites in human macrophages, a phenomenon involving the production of tumor necrosis factor alpha and nitric oxide (NO). Based upon various in vitro and in vivo studies of human cutaneous leishmaniasis, Djavad Mossalayi, Michel Arock, Dominique Mazier, Philipe Vincendeau and Ioannis Vouldoukis here propose a model for an immune response that involves CD23-IgE-mediated NO release during protection, as well as during active cutaneous leishmaniasis.

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Keywords

active cutaneous leishmaniasis
 
Djavad Mossalayi
 
host protection
 
human cutaneous leishmaniasis
 
human macrophages
 
immune response
 
Ioannis Vouldoukis
 
Leishmania parasites
 
Michel Arock
 
Philipe Vincendeau
 
plasma IgE
 
tumor necrosis factor alpha
 
various
 
vivo studies