Article

Persistent infantile hypothyroidism attributable to thyroxine-binding globulin deficiency.

University of Wisconsin Children's Hospital, 600 Highland, Avenue, Madison, WI 53792, USA.
Pediatrics (impact factor: 5.44). 09/1999; 104(2 Pt 1):312-4. pp.312-4
Source: PubMed

ABSTRACT An infant diagnosed with thyroid-binding globulin (TBG) deficiency after newborn screening demonstrated persistent elevation of thyroid-stimulating hormone (TSH) and abnormally low free thyroxine (fT4) levels. Treatment with thyroxine (T4) normalized fT4 and TSH levels during the first 5 years of life, but withdrawal of T4 supplementation at that time was associated with return of hyperthyrotropinemic hypothyroidism. To our knowledge, this patient is the first reported case of TBG deficiency-associated hypothyroidism. In rare instances, TBG deficiency may lead to hypothyroidism requiring hormone supplementation.

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Keywords

abnormally low free thyroxine
 
hyperthyrotropinemic hypothyroidism
 
hypothyroidism
 
persistent elevation
 
rare instances
 
T4 supplementation
 
TBG
 
TBG deficiency
 
TBG deficiency-associated hypothyroidism
 
thyroid-binding globulin
 
thyroxine
 
TSH levels
 

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