Article

Mast cell sarcoma with tissue eosinophilia arising in the ascending colon.

Department of Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
Modern Pathology (Impact Factor: 6.36). 08/1999; 12(7):739-43.
Source: PubMed

ABSTRACT Mast cell sarcoma is a rare disease. We report an unusual case of this neoplasm arising in the ascending colon of a 32-year-old Japanese woman who presented with abdominal pain. An ulcerating mass in the colon was resected, along with enlarged mesenteric lymph nodes. Two years after surgery, the neoplasm recurred as left cervical lymphadenopathy and an intra-abdominal mass. Despite predonine and radiation therapy, the disease progressed, and the patient died. The tumor cells had abundant fine granular or clear cytoplasm, and oval, lobulated, or indented nuclei. Numerous mature eosinophils were intermingled with the tumor cells. Immunohistologic studies on paraffin sections demonstrated that the majority of the tumor cells were strongly positive for CD45RB, CD68, and mast cell tryptase. They were unreactive, however, with a broad spectrum of antibodies against myelomonocytic and lymphocytic antigens. The mast cell nature of this rare type of tumor can be best identifiable by immunostains for mast cell tryptase.

0 Followers
 · 
99 Views
  • Annals of Hematology 10/2013; 93(6). DOI:10.1007/s00277-013-1931-x · 2.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Mastocytosis encompasses a group of clinically and pathologically heterogeneous disorders most commonly involving the skin, which typically takes the form of urticaria pigmentosa. Mastocytosis may also involve other organs, most often bone marrow, followed by gastrointestinal tract, liver, spleen, and lymph nodes. The presence of extracutaneous involvement by mastocytosis is a major diagnostic criterion for systemic disease. However, mast cell infiltrates are often subtle in skin and extracutaneous organs, and the histologic features of mastocytosis at different anatomic sites may be variable. This article reviews the pathologic features and clinical correlates of mastocytosis involving skin and other extramedullary sites.
    Immunology and allergy clinics of North America 05/2014; 34(2):323-339. DOI:10.1016/j.iac.2014.01.010 · 2.22 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Mast cell sarcoma is a disorder that results in abnormal mast cells as identified by morphology, special stains, and in some publications, c-kit mutation analysis. It affects animal species such as canines more commonly than humans. In humans it is a very rare condition, with variable clinical presentation. There is no standard therapy for the disorder. It can affect any age group. It is occasionally associated with systemic mastocytosis and/or urticaria pigmentosa. The prognosis of mast cell sarcoma in published literature is very poor in humans.
    Immunology and allergy clinics of North America 05/2014; 34(2):423-432. DOI:10.1016/j.iac.2014.01.004 · 2.22 Impact Factor