Article

Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).

Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Neuroscience Letters (impact factor: 2.11). 08/1999; 269(2):115-9. pp.115-9
Source: PubMed

ABSTRACT Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib transmission disequilibrium test (S-TDT) was also used to test for differences in BCHE-K allele frequencies between 163 discordant sib-pairs selected from multiplex AD families. No statistically significant differences were noted between BCHE-K case and control allele frequencies even after stratifying by APOE4 status. S-TDT analysis between the BCHE-K variant and AD was also not significant (P = 0.52). We conclude that BCHE-K is not a major genetic risk factor for AD in our study population.

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Keywords

163 discordant sib-pairs
 
245 sporadic AD cases
 
Alzheimer disease
 
APOE4 status
 
BCHE-K
 
BCHE-K allele frequencies
 
BCHE-K case
 
BCHE-K variant
 
Butyrylcholinesterase
 
chi-square analyses
 
control allele frequencies
 
increased odds
 
K variant
 
major genetic risk factor
 
multiplex AD families
 
sib transmission disequilibrium test
 
statistically significant differences
 
study population