Cervical metastasis of occult papillary thyroid carcinoma associated with epidermoid carcinoma of the larynx.

Department of Otorhinolaryngology, Hospital Universitario Virgen de las Nieves, Granada, Spain.
ORL (Impact Factor: 0.67). 01/1999; 61(4):224-6. DOI: 10.1159/000027676
Source: PubMed

ABSTRACT An occult, laterocervical papillary thyroid carcinoma tissue was found in a functional neck dissection for larynx cancer. The patient was a 76-year-old man with a history of smoking and alcohol ingestion who presented with a supraglottic carcinoma of the larynx located at the laryngeal surface of the epiglottis, left aryepiglottic fold, band and left ventricle with extension to the left vocal cord. Light microscopy showed a lymph node with a fibrous stroma with lymphoid follicles that presented a total substitution of the parenchyma by a papillary thyroid carcinoma. Although examination of the thyroid gland by seriated sections did not reveal any neoplasm, we argue that the papillary thyroid tissue is metastatic.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Thyroid carcinomas have been found incidentally in the cervical lymph nodes during surgery for head and neck squamous cell carcinoma (SCC). Such carcinomas have been considered a metastatic focus for malignant transformation of heterotopic thyroid tissue. We report on cases of so-called occult thyroid carcinoma in the cervical lymph nodes, and review the relevant literature. We encountered 3 cases of incidental papillary carcinoma in the cervical lymph nodes of patients with oral SCC, and consequently reviewed 75 previously reported cases. Among 148 patients with oral SCC who had undergone cervical lymph node dissection, 3 were diagnosed with occult thyroid carcinoma. Papillary carcinomas were found in 3, 10, and 3 lymph nodes in cases 1, 2, and 3, respectively. Computed tomography showed 2 tumor-like shadows and 1 calcified mass in the thyroid gland in cases 2 and 3, respectively. These shadows did not enlarge during the 3 to 5 years of observation, and all patients are alive, without any events related to the neck and thyroid gland. Among the reviewed cases, approximately two fifths were histopathologically or clinically free from thyroid carcinoma. Progressive thyroid carcinoma was not detected in any patient. We propose the possibility that thyroid carcinoma in the cervical lymph nodes is not necessarily metastatic, but may occasionally arise from heterotopic thyroid tissue.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 01/2009; 66(12):2566-76. · 1.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study was carried out to address the dilemma of managing incidentally associated squamous cell carcinoma of the head and neck and thyroid carcinoma. The patient group consists of 229 consecutive cases of squamous cell carcinoma of the head and neck and who were treated surgically at the Uludag University School of Medicine Department of Otolaryngology over a four-year period between 1997 and 2000. Among these patients, 3 had additional thyroid papillary carcinoma metastases (1.3%, 3/229) within the surgical specimens of the surgical procedures performed for squamous cell carcinoma of the head and neck. Complementary thyroidectomy was recommended but could not be performed in one of three cases because of the patient's refusal, and the primary focus of thyroid carcinoma could be found in only one of these two cases who had undergone complementary thyroidectomy. All three patients received postoperative radioactive iodine and thyroid hormone suppression, and all are free of disease after 49, 46, and 19 months of follow-up, respectively. Management of thyroid carcinoma found incidentally during treatment of squamous cell carcinoma of the head and neck is still debatable, and all patients must be evaluated individually with regard to its benefit. Our limited experience suggests that total thyroidectomy may not be regarded as mandatory in managing these patients.
    American Journal of Otolaryngology 07/2002; 23(4):228-32. · 1.08 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ectopic thyroid tissue is rarely seen in the cervical lymph node. Thyroid carcinomas most commonly arise within the thyroid gland. Ectopic thyroid carcinoma arising in the cervical lymph node is extremely rare. Here we report a case of papillary thyroid carcinoma arising from ectopic thyroid tissue within a lateral cervical lymph node. Pathological examination revealed papillary thyroid carcinoma and non-neoplastic thyroid tissue in the cervical lymph node. No other abnormality was found in the thyroid gland or cervical region at a postoperative follow-up of 11 years. In this patient, the carcinoma was likely derived from malignant transformation of ectopic thyroid tissue in the cervical lymph node rather than cervical lymph node metastasis of primary thyroid carcinoma.
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 04/2014;