Oxidative stress induced by exercise and dietary fat modulates the coenzyme Q and vitamin A balance between plasma and mitochondria.
ABSTRACT Physical exercise induces oxidative stress. Dietary fat modulates lipid composition of plasma and fatty acid profile of mitochondrial membranes. Over 8 wk, two groups of rats were fed virgin olive oil or sunflower oil as the only fat sources. Both groups were divided into 4 subgroups according to exercise: one of sedentary rats and the other three of rats subjected to different exercises on a treadmill. There was a lower concentration of vitamin A and coenzyme Q in the plasma of animals subjected to exercise compared to the sedentary animals. The concentrations of these molecules in liver and skeletal muscle mitochondria of animals exercised until exhaustion were higher than in sedentary animals. This can suggest the existence of a balance between plasma and mitochondrial membrane for these antioxidants as a response to an oxidative attack.
Article: Role of olive oil and monounsaturated fatty acids in mitochondrial oxidative stress and aging[show abstract] [hide abstract]
ABSTRACT: The free radical theory of aging argues that free radicals produced by the mitochondria are responsi-ble for the damage that affects all biological tissues and leads to the aging phenotype. High olive oil intake is related to lower mitochondrial oxidative stress, including that which happens during aging. The de-gree of fatty acid unsaturation of mammalian tissues is also negatively correlated with greater longevity, and olive oil leads to less polyunsaturated biological membranes. Finally, monounsaturated fatty acids (such as those of olive oil) have been associated with greater longevity and a high degree of protection against age-related cognitive decline in humans.11/2006;
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ABSTRACT: Exercise is one of the factors that stimulate the aerobic metabolism, leading to an increased generation of reactive oxygen species (ROS). Mammals, including humans, have a complex antioxidant structure, which protects them against the toxic effects of ROS. This structure includes antioxidant enzymes and non-enzymatic scavengers of oxygen derived free radicals (ODFR). A disturbance in the pro- and antioxidant balance leads to oxidative stress, which often accompanies strenuous exercise. As a result of the excessive generation of ODFR, damage occurs to lipids, nucleic acids and the modification of proteins. Physical training alleviates the results of oxidative stress, mainly through an adaptable increase in the activity of antioxidant enzymes.Biology of Sport. 01/2003;