Article

[IL-2, IFN-gamma, and TNF-alpha mRNA expression in peripheral blood mononuclear cells in patients with multiple sclerosis].

Institute of Basic Medical Sciences, CAMS, Beijing.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 03/1997; 19(1):24-8. pp.24-8
Source: PubMed

ABSTRACT We determined the cytokine messenger RNA (mRNA) expression patterns of peripheral blood mononuclear cells from 17 patients with multiple sclerosis (MS) and 11 normal controls, by using a quantitative reverse transcription in combination with polymerase reaction (RT/PCR) and Southern blot hybridization method. A significantly higher levels of IL-2, IFN-gamma mRNA in patient with MS compared to normal controls and significantly higher level of expressions of IFN-gamma, TNF-alpha mRNA were detected in active MS patients compared to those with stable desease (P < 0.05). These data further support the central role of some cytokines in the pathophysiology of this autoimmune disease.

0 0
 · 
0 Bookmarks
 · 
16 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

11 normal controls
 
active MS patients
 
cytokine messenger RNA
 
expressions
 
IFN-gamma mRNA
 
mRNA
 
multiple sclerosis
 
normal controls
 
pathophysiology
 
peripheral blood mononuclear cells
 
polymerase reaction
 
quantitative reverse transcription
 
Southern blot hybridization method
 
stable desease
 
TNF-alpha mRNA