Clinical features of Wolff-Parkinson-White syndrome

Department of Medicine, Duke University, Durham, North Carolina, United States
American Heart Journal (Impact Factor: 4.56). 10/1999; 138(3 Pt 1):403-13. DOI: 10.1016/S0002-8703(99)70140-7
Source: PubMed

ABSTRACT Wolff-Parkinson-White syndrome is the most common form of ventricular preexcitation. Understanding this syndrome is fundamental for anyone interested in learning about arrhythmias. This review addresses (1) the historic sequence of events that led to the understanding of this syndrome; (2) the pathologic, embryologic, and electrophysiologic properties of accessory pathways; (3) the epidemiology and genetics of this syndrome; (4) the clinical diagnosis of this syndrome, with special emphasis on the arrhythmias that patients with ventricular preexcitation are predisposed to; and (5) the therapy for patients with Wolff-Parkinson-White syndrome.

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    07/2010; 40(2):10-13. DOI:10.1007/s12534-010-0097-8
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    ABSTRACT: The Wolff-Parkinson-White (WPW) syndrome is the commonest form of ventricular pre-excitation and is characterised by the presence of an accessory pathway between atria and ventricles. The term WPW syndrome is applied to patients with both pre-excitation on the ECG and paroxysmal tachycardia. Usually the conducting properties of bypass tracts and the AV node differ, the ventricular response during atrial flutter or fibrillation may be unusually rapid and may cause ventricular fibrillation. Atrial fibrillation (AF) is not an uncommon presentation in emergency department. Moreover, AF associated with WPW syndrome as an underlying condition is also not a rare occurrence; it is seen in 20-25% of WPW Syndrome. Recognition of this condition is very crucial in terms of emergency management. Its early recognition and initial treatment allows rapid restoration to sinus rhythm. Acute management of WPW syndrome with atrial fibrillation with hypotension is DC cardioversion. In haemodynamically stable patients, the drugs of choice are Amiodarone and class Ic anti-arrhythmic agents.
    12/2010; 6(3). DOI:10.3126/jcmsn.v6i3.4078