Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med

School of Biomedical Sciences, University of Wales Institute, Cardiff, UK.
Journal of the Royal Society of Medicine (Impact Factor: 2.12). 07/1999; 92(6):283-5.
Source: PubMed


The antibacterial action of honey in infected wounds does not depend wholly on its high osmolarity. We tested the sensitivity of 58 strains of coagulase-positive Staphylococcus aureus, isolated from infected wounds, to a pasture honey and a manuka honey. There was little variation between the isolates in their sensitivity to honey: minimum inhibitory concentrations were all between 2 and 3% (v/v) for the manuka honey and between 3 and 4% for the pasture honey. Thus, these honeys would prevent growth of S. aureus if diluted by body fluids a further seven-fold to fourteen-fold beyond the point where their osmolarity ceased to be completely inhibitory. The antibacterial action of the pasture honey relied on release of hydrogen peroxide, which in vivo might be reduced by catalase activity in tissues or blood. The action of manuka honey stems partly from a phytochemical component, so this type of honey might be more effective in vivo. Comparative clinical trials with standardized honeys are needed.

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    • "The antioxidants found in honey work on wounds through two means. First, the antioxidants fight against microorganisms and decrease infections at the site of the wound [60] [61] [62]. Second, the antioxidants reduce reactive oxygen species (ROS) and inflammations caused by the wound and aid in the healing process [62] [63] [64] [65]. "
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    ABSTRACT: Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound healing since ancient times, the application of honey to diabetic wounds has only recently been revived. Because honey has some unique natural features as a wound healer, it works even more effectively on diabetic wounds than on normal wounds. In addition, honey is known as an "all in one" remedy for diabetic wound healing because it can combat many microorganisms that are involved in the wound process and because it possesses antioxidant activity and controls inflammation. In this review, the potential role of honey's antibacterial activity on diabetic wound-related microorganisms and honey's clinical effectiveness in treating diabetic wounds based on the most recent studies is described. Additionally, ways in which honey can be used as a safer, faster, and effective healing agent for diabetic wounds in comparison with other synthetic medications in terms of microbial resistance and treatment costs are also described to support its traditional claims.
    Evidence-based Complementary and Alternative Medicine 10/2014; 2014:1-16. DOI:10.1155/2014/169130 · 1.88 Impact Factor
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    • "Honey, a best blend of sugars, is known since ancient time for its topical antimicrobial activity and has been used to treat ulcers and wounds (Molan 1992; Cooper et al., 1999). At first osmolarity of honey was thought to exert lethal effect on microbes but antimicrobial action of honey even after decimal dilution ward off the hypothesis (Cooper et al., 1999). Thereafter, release of hydrogen peroxide from honey was thought to be important reason behind the antimicrobial activity but that too is too low to cause the death of microbes (Molan, 1992). "
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    ABSTRACT: In the study antimicrobial activity of adonitol, arabinose, cellobiose, dulcitol, galactose, glycerol, glucose, inositol, lactose, maltose, mannitol, mannose, mellibiose, raffinose, salicin, sorbitol, sucrose, trehalose and xylose was determined on 96 strains of Bacillus anthracoides, 3; Bacillus badius, 5; Bacillus brevis (3), Bacillus circulans (4), Bacillus coagulans (3), Bacillus lentus (6); Bacillus marcerans (3), Bacillus pantothenticus (15), Citrobacter amalonaticus (3), Citrobacter diversus (1), Enterobacter agglomerans (2), Enterobater gregoviae (1), Enterococcus asacchrolyticus (1), Enterococcus avium (4), Enterococcus caecorum (8), Enterococcus gallinarum (2), Enterococcus malodoratus (1), Enterococcus mundtii (1), Enterococcus raffinosus (4), Ervinia ananas (1), Klebsiella oxytoca (2), Microcccus luteus (2), Morganella morganii (2), Proteus mirabilis (9), Proteus vulgaris (6), Providencia rettgeri (3) and Pseudomonas aeruginosa (1). Of the 19 sugars tested on 96 strains only glycerol, lactose, maltose, mannitol, raffinose and xylose had bacteriostatic effect against 1, 1, 6, 4, 4 and 3 strains, respectively. Of the 18 strains sensitive to one or other sugar none of the strains was sensitive to more than one sugar except a strain of C. diversus sensitive to raffinose and xylose. Sugar sensitive strains belonged to 11 species of Bacillus (5), Citrobacter (1), Enterococcus (3), Proteus (1) and Providencia (1) genus.
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    • "Associated bee brood (larvae and pupae), which are consumed simultaneously, also provide high amounts of protein, fat, and B-vitamins (Finke, 2005). As a result of such high micronutrient diversity, honey has many functional properties desired by humans, such as long preservation time (Nagai et al., 2006) and antimicrobial (Molan, 1992a,b; Cooper et al., 1999), antiviral, antiparasitory, antiinflammatory , and antioxidant effects (Bogdanov et al., 2008). Thus, it is perhaps unsurprising that honey is a prized resource among hunter-gatherers (Ichikawa, 1981; O'Dea et al., 1991; Chagnon, 1992; Marlowe and Berbesque, 2009), particularly in rainforests where carbohydrate-rich food resources are scarce (Hart and Hart, 1986; Headland, 1987). "
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    Journal of Human Evolution 06/2014; 71:105-118. DOI:10.1016/j.jhevol.2014.02.002 · 3.73 Impact Factor
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