Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds.

School of Biomedical Sciences, University of Wales Institute, Cardiff, UK.
Journal of the Royal Society of Medicine (Impact Factor: 2.02). 07/1999; 92(6):283-5.
Source: PubMed

ABSTRACT The antibacterial action of honey in infected wounds does not depend wholly on its high osmolarity. We tested the sensitivity of 58 strains of coagulase-positive Staphylococcus aureus, isolated from infected wounds, to a pasture honey and a manuka honey. There was little variation between the isolates in their sensitivity to honey: minimum inhibitory concentrations were all between 2 and 3% (v/v) for the manuka honey and between 3 and 4% for the pasture honey. Thus, these honeys would prevent growth of S. aureus if diluted by body fluids a further seven-fold to fourteen-fold beyond the point where their osmolarity ceased to be completely inhibitory. The antibacterial action of the pasture honey relied on release of hydrogen peroxide, which in vivo might be reduced by catalase activity in tissues or blood. The action of manuka honey stems partly from a phytochemical component, so this type of honey might be more effective in vivo. Comparative clinical trials with standardized honeys are needed.

  • Source
  • [Show abstract] [Hide abstract]
    ABSTRACT: We review herein the basis for using dietary components to treat and/or prevent Helicobacter pylori infection, with emphasis on (a) work reported in the last decade, (b) dietary components for which there is mechanism-based plausibility, and (c) components for which clinical results on H pylori amelioration are available. There is evidence that a diet-based treatment may reduce the levels and/or the virulence of H pylori colonization without completely eradicating the organism in treated individuals. This concept was endorsed a decade ago by the participants in a small international consensus conference held in Honolulu, Hawaii, USA, and interest in such a diet-based approach has increased dramatically since then. This approach is attractive in terms of cost, treatment, tolerability, and cultural acceptability. This review, therefore, highlights specific foods, food components, and food products, grouped as follows: bee products (eg, honey and propolis); probiotics; dairy products; vegetables; fruits; oils; essential oils; and herbs, spices, and other plants. A discussion of the small number of clinical studies that are available is supplemented by supportive in vitro and animal studies. This very large body of in vitro and preclinical evidence must now be followed up with rationally designed, unambiguous human trials. Copyright © 2015. Published by Elsevier Inc.
    Nutrition research 03/2015; DOI:10.1016/j.nutres.2015.03.001 · 2.59 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Antibacterial potential of four lemongrass essential oils (EOs) and their major oil constituent, citral in single form and in combination of honey were evaluated against multi drug resistant (MDR) bacteria Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus. The antibacterial potentials determined using agar well diffusion method has revealed that Krishna EOs exhibited most potent bactericidal effects than other Eos against all MDR bacteria used. The diameter of zone of inhibition of Krishna EOs ranged from 44-50 mm/50 µL of EOs. However, EOs of Pragati and Suvarna were selectively effective against S. aureus while that of Nima against A. baumannii and P. aeruginosa. Citral expressed better antibacterial potential against all the MDR bacteria with zone of inhibition 38-45 mm/50 µl. The combination of all four different EOs with honey showed pronounced antibacterial activity exclusively against S. aureus. The combination of Suvarna EOs and honey showed 22 % increase in antibacterial activity against A. baumannii than the EOs alone. The combination of citral and honey showed significantly lower antibacterial activity as compared to citral alone against all MDR bacteria used. The minimum inhibitory concentrations of EOs determined were 4.5 µg/ml. Thus, the study revealed enhanced antibacterial potential of lemongrass EO when they are used with honey against drug resistant S. aureus.
    07/2014; 4(4). DOI:10.1080/22311866.2014.933083


Available from