Article

Characteristics of the cohort of workers at the Mayak nuclear complex

Branch No. 1 of the State Research Center "Biophysics Institute", Ozyorsk, Chelyabinsk region, Russia.
Radiation Research (Impact Factor: 2.45). 11/1999; 152(4):352-63. DOI: 10.2307/3580220
Source: PubMed

ABSTRACT At Branch No. 1 of the Russian State Research Center "Biophysics Institute", a registry has been created of workers at the "Mayak" Production Association, the first nuclear complex in Russia. This registry includes 18,830 persons hired at Mayak's nuclear reactors and radiochemical and plutonium production plant between 1948 and 1972. Twenty-five percent of these workers are women. As of December 31, 1994, the vital status is known for approximately 90% of the cohort members. A total of 5,118 persons have died. The cause for 97% of total deaths has been ascertained. The cohort members were exposed to both external gamma radiation and internal radiation from incorporated plutonium. The plutonium body burden has been measured in 30% of the cohort members with potential for plutonium exposure. External gamma-ray doses were in the range from tenths of milligrays to about 10 Gy, and plutonium body burdens were up to about 260 kBq. In view of the nature of the Mayak worker cohort, it has the potential to provide reasonably precise, quantitative estimates of the long-term health effects associated with chronic low-dose-rate exposure to external gamma radiation as well as internal radiation from plutonium. However, a number of issues must be addressed before credible risk estimates can be obtained from this cohort. These issues include the development of an appropriate internal comparison group and/or external rates and separating of the effects of internal and external exposures on risk estimates.

2 Followers
 · 
108 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The research objective was establishment of the Human Radiobiology Tissue Repository (HRTR) for collection and storage of biological material for its further utilization in research on health effects of protracted radiation exposure. The HRTR consists of three constantly replenished banks of biomaterial from nuclear workers. The autopsy tissue bank contains formalin-fixed tissues, paraffin blocks and histological slides from 900 cases. The surgery/biopsy tissue bank contains tumor tissues from various sites and samples of lymphoid, bone and other tissues stored at -78°С (200 cases). The blood bank stores leukocytes, immortalized B-lymphocytes, erythrocytes, blood plasma and DNA from 1,200 individuals at -78°С and -160°С. The occupational, dosimetry and detailed medical information is available for each donor.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background:Cancer incidence in the Mayak Production Association (PA) cohort was analysed to investigate for the first time whether external gamma-ray and internal plutonium exposure are associated with raised incidence of solid cancers other than lung, liver and bone (other solid cancers).Methods:The cohort includes 22 366 workers of both sexes who were first employed between 1948 and 1982. A total of 1447 cases of other solid cancers were registered in the follow-up period until 2004. The Poisson regression was used to estimate the excess relative risk (ERR) per unit of cumulative exposure to plutonium and external gamma-ray.Results:A weak association was found between cumulative exposure to external gamma-ray and the incidence of other solid cancers (ERR/Gy=0.07; 95% confidence intervals (CIs): 0.01-0.15), but this association lost its significance after adjusting for internal plutonium exposure. There was no indication of any association with plutonium exposure for other solid cancers. Among 16 individual cancer sites, there was a statistically significant association with external exposure for lip cancer (ERR/Gy=1.74; 95% CI: 0.37; 6.71) and with plutonium exposure for pancreatic cancer (ERR/Gy=1.58; 95% CI; 0.17; 4.77).Conclusion:This study of Mayak workers does not provide evidence of an increased risk of other solid cancers. The observed increase in the risk of cancer of the lip and pancreas should be treated with caution because of the limited amount of relevant data and because the observations may be simply due to chance.British Journal of Cancer advance online publication, 10 September 2013; doi:10.1038/bjc.2013.543 www.bjcancer.com.
    British Journal of Cancer 09/2013; 109(7). DOI:10.1038/bjc.2013.543 · 4.82 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We present an updated analysis of incidence and mortality from atherosclerotic induced ischemic heart diseases in the cohort of workers at the Mayak Production Association (PA). This cohort constitutes one of the most important sources for the assessment of radiation risk. It is exceptional because it comprises information on several other risk factors. While most of the workers have been exposed to external gamma radiation, a large proportion has additionally been exposed to internal radiation from inhaled plutonium. Compared to a previous study by Azizova et al. 2012, the updated dosimetry system MWDS-2008 has been applied and methods of analysis have been revised. We extend the analysis of the significant incidence risk and observe that main detrimental effects of external radiation exposure occur after more than about 30 years. For mortality, significant risk was found in males with an excess relative risk per dose of 0.09 (95% CI: 0.02; 0.16) [Formula: see text] while risk was insignificant for females. With respect to internal radiation exposure no association to risk could be established.
    PLoS ONE 05/2014; 9(5):e96309. DOI:10.1371/journal.pone.0096309 · 3.53 Impact Factor