Primary Hepatic Diffuse Large B-Cell Lymphoma in a Patient with Chronic Hepatitis C

Division of Clinical Pathology, University Hospital, Geneva, Switzerland.
American Journal of Surgical Pathology (Impact Factor: 5.15). 10/1999; 23(9):1124-30. DOI: 10.1097/00000478-199909000-00017
Source: PubMed


Epidemiological and experimental data suggest that the hepatitis C virus infection might be associated with the development of distinct types of non-Hodgkin's lymphomas. Here, we report a case of a patient with chronic hepatitis C and type II mixed cryoglobulinemia, who developed a primary hepatic non-Hodgkin's B-cell lymphoma. A diffuse, large B-cell lymphoma was diagnosed based on morphological, immunophenotypical and molecular genetic findings. Hepatitis C virus replication, as evaluated by strand-specific reverse transcriptase-polymerase chain reaction, was detected in the nonneoplastic liver, but not in the lymphomatous tissue. High grade non-Hodgkin's lymphomas, although rare complications, have to be considered as part of the spectrum of hepatitis C virus-related hepatic lesions.

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