Autoantibody disturbances in affective disorders: a function of age and gender?
ABSTRACT Numerous investigators have reported increased autoantibodies to a wide variety of native antigens in patients with affective disorders. However, association of autoimmunity with affective subtypes, mood state, psychotropic medications, age, and gender has not been extensively explored.
The present study assessed 79 bipolar I, 24 bipolar II, and 46 unipolar major depression patients along with 22 healthy, nonpsychiatric controls for the presence of serum antinuclear (ANA), anti-double stranded DNA, antithyroid microsomal, antithyroglobulin, anticardiolipin (ACA) IgM, and ACA IgG antibodies.
Consistent with their higher prevalence of autoimmune disease, women exhibited increased levels of ANA and ACA IgM compared to men. ACA IgG antibody titers also increased significantly with age. Contrary to prior reports of general, overall increases in autoantibodies and specific increases in ANA and antithyroid antibodies in depressed patients, we did not see a significant association between any of the autoantibodies and affective subtype, mood state, or psychotropic medications.
Affective subgroups were heterogeneous with respect to psychotropic medications, affective state, age, and gender in this retrospective analysis. Subgroup sample size was insufficient to determine whether interactions of these clinical variables may have influenced results.
These results suggest that gender and age may have more influence on autoantibodies than affective diagnosis, affective state, or medications.
SourceAvailable from: Marc De HertWorld psychiatry: official journal of the World Psychiatric Association (WPA) 06/2014; 13(2):189-92. DOI:10.1002/wps.20117 · 12.85 Impact Factor
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ABSTRACT: Our data represent a strong non-confirmative association between the relevance of thyroid function and thyroid autoimmunity in bipolar disorders.•The sample size and the parallel design are the main strengths of the study.•The study underscores the relevance of pharmacological treatments in the metabolism of thyroidal hormones, especially lithium.•The study did not support a familial aggregation (or endophenotype) of thyroidal antibodies positivization in pedegrees of bipolar I disorder.Psychoneuroendocrinology 01/2015; 51. DOI:10.1016/j.psyneuen.2014.09.032 · 5.59 Impact Factor
Article: Immunology of bipolar disorder[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. METHODS: Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor necrosis factor" were selected in a systematic review of the literature. The evaluated databases were MedLine and Scopus in the period between 1980 and 2008. RESULTS: Twenty eight works were found. Six studies investigated immune response-related genes; five, auto-antibodies; four, leukocyte population; 13, cytokines and/or immune-related molecules; six, leukocytes in vitro. CONCLUSIONS: Although there is evidence in the literature correlating affective disorders with immune parameters, the results are still inconclusive. Bipolar disorder seems to be associated with increased levels of auto-antibodies as well as with a trend for increased immune activation with production of pro-inflammatory cytokines and reduction of the anti-inflammatory parameters.Jornal brasileiro de psiquiatria 12/2008; 58(1):52-59.