Article

Catechol-O-methyltransferase and Gilles de la Tourette syndrome.

The Department of Psychiatry, Toronto Hospital Western Division, Toronto, Ontario, Canada.
Molecular Psychiatry (impact factor: 13.67). 10/1999; 4(5):492-5. pp.492-5
Source: PubMed

ABSTRACT Gilles de la Tourette syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. Individuals with TS often have symptoms of obsessive compulsive disorder (OCD) and these symptoms are thought to be an alternative expression of the TS gene(s) in TS families. In this paper we test for linkage of the functional polymorphism in the catechol-O-methyltransferase (COMT) gene to TS and OCD in five multi-generational families ascertained through a TS proband. This polymorphism (valine to methionine at codon 158) has been previously reported to influence the activity of COMT by three to four-fold and has recently been reported to be associated with OCD.1 We tested for linkage using an autosomal dominant model with reduced penetrance and non-parametric methods. No significant evidence for linkage was found for the COMT gene and the TS/CMT, or OCD phenotypes in these pedigrees.

0 0
 · 
0 Bookmarks
 · 
20 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

alternative expression
 
autosomal dominant model
 
COMT
 
COMT gene
 
four-fold
 
Gilles de la Tourette syndrome
 
linkage
 
multi-generational families ascertained
 
neuropsychiatric disorder
 
non-parametric methods
 
obsessive compulsive disorder
 
penetrance
 
significant evidence
 
symptoms
 
TS
 
TS families
 
TS gene(s)
 
TS proband
 
TS/CMT
 
vocal tics