Reactive or infectious arthritis

Hochschule Hannover, Hanover, Lower Saxony, Germany
Annals of the Rheumatic Diseases (Impact Factor: 10.38). 12/1999; 58(11):661-4. DOI: 10.1136/ard.58.11.661
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Available from: Henning Zeidler, Feb 16, 2015
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    ABSTRACT: Reactive Arthritis (ReA) is an aseptic synovitis developing after a primary infection distant from the joint, mainly localized in the gastrointestinal (Enteroarthritis) or genitourinary tract (Uroarthritis). Because of either the asymmetric joint involvement, the possibility of involvement of the spine and enthesis, and the HLA-B27 association ReA is considered one of the spondylarthropathies. Recently, bacterial components or viable bacteria were found in joints during ReA. For this reason, the limits between ReA itself and infectious arthritis are now less definite. Generally accepted diagnostic and classification criteria are still lacking but the improvement in techniques for detection of bacteria increase the possibility to identify the triggering agents. Several studies have examined the role of antimicrobial drugs in ameliorating the natural course of ReA, with some positive results for Uroarthritis only. However, more conventional treatments based on NSAIDs, sulfasalazine and steroids are effective in many cases.
    Reumatismo 09/2011; 54(2):105-12. DOI:10.4081/reumatismo.2002.105
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    ABSTRACT: by Moll et al. (2) the school of 'lumpers', who preferred Infection of the urogenital or gastrointestinal tract to group the so-called 'variants of rheumatoid arthritis' Alteration of the skin (psoriasiform skin or nail lesion, with rheumatoid arthritis itself, were overcome by the erythema nodosum) school of 'splitters', prompted by the idea that these Buccal ulceration of the mouth, small or large intestine and seronegative arthritides were, in fact, entirely separate urogenital tract Thrombophlebitis entities. This change was mirrored by the Nomenclature Pyoderma gangraenosum and Classification of the Rheumatic Diseases proposed Familial aggregation by the American Rheumatism Association in 1963 (1). Association with HLA-B27 Rheumatoid arthritis, juvenile Still's disease, ankylosing spondylitis, psoriatic arthritis, and Reiter's syndrome 1. The term seronegative arthritis still survives and is were then classified under separate headings with the not completely out of use, which may be illustrated common denominator 'polyarthritis of unknown origin'. by the fact that the Editor of this journal initially
    Rheumatology 05/2000; 39(4):360-8. DOI:10.1093/rheumatology/39.4.360 · 4.48 Impact Factor
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    ABSTRACT: During the past year, no big advances were reported in understanding the pathogenesis or treatment of reactive arthritis (ReA). The need for generally accepted diagnostic criteria has become a central issue. Regarding pathogenesis, attention has been drawn to a similarity between ReA and the experimental antigen-induced arthritis. Molecular mechanisms of the HLA-B27-associated pathogenesis have remained, in spite of intensive research, so far a mystery. It is apparent that antibiotics have no effect on the fully developed reactive arthritis, with the exception of patients with Chlamydia-triggered ReA, who might benefit from a course of antibiotics.
    Current Opinion in Rheumatology 07/2000; 12(4):300-5. DOI:10.1097/00002281-200007000-00012 · 4.89 Impact Factor
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