A Bone marrow biopsy technique suitable for use in neonates
Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA.British Journal of Haematology (Impact Factor: 4.71). 12/1999; 107(2):458-60. DOI: 10.1046/j.1365-2141.1999.01712.x
Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow aspirates, we devised a biopsy technique which we successfully applied to five cytopenic neonates (three with severe persistent thrombocytopenia and two with idiopathic neutropenia). This technique used a 19 gauge, half-inch Osgood needle to obtain bone marrow clots from the tibias of small preterm neonates which enabled the assessment of marrow cellularity and architecture. On the basis of our initial experience we have ceased using the traditional bone marrow aspiration technique in neonates and now use this technique exclusively.
Full-textDOI: · Available from: Martha Sola-Visner, Nov 25, 2014
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ABSTRACT: Neutropenia is a relatively common problem in the NICU, recognized in as many as 8% of patients at some time during their hospital stay. In most instances, neutropenia among NICU patients is of short duration and has little influence on outcome. In other cases it is prolonged and severe, and constitutes a serious antimicrobial defense deficiency. When a neonatologist discovers a low blood neutrophil count, choices must be made regarding further evaluation and treatment. The authors hope that the information provided in this article is useful in making these choices.Clinics in Perinatology 10/2000; 27(3):577-601. DOI:10.1016/S0095-5108(05)70040-3 · 2.44 Impact Factor
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ABSTRACT: Thrombocytopenia is a very frequent problem among sick neonates, affecting up to 35% of all infants admitted to the NICU. Although multiple clinical conditions have been causally associated with neonatal thrombocytopenia, the cause of the thrombocytopenia is unclear in up to 60% of affected neonates. This article provides neonatologists with a practical approach to the thrombocytopenic neonate, with an emphasis on conditions that could be life-threatening or could have significant implications for further pregnancies. An overview of the current therapeutic modalities is also presented, including a discussion of the possible use of recombinant thrombopoietic cytokines to treat certain groups of thrombocytopenic neonates.Clinics in Perinatology 10/2000; 27(3):655-79. DOI:10.1016/S0095-5108(05)70044-0 · 2.44 Impact Factor
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