Phosphaturic Mesenchymal Tumor-Induced Rickets
Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520, USA.Pediatric and Developmental Pathology (Impact Factor: 0.87). 12/1999; 3(1):61-9. DOI: 10.1007/s100249910008
We describe two prepubertal girls with oncogenic rickets. The first patient, 9 years of age, presented with recent-onset lower-extremity pain. The second girl, presented at 4 years of age following a 9-month period of muscle weakness, bone pain, and poor linear growth. Laboratory analyses in both patients revealed hypophosphatemia and hyperphosphaturia; elevated circulating alkaline phosphatase activity was present in one of them. Radiographic evidence of a generalized rachitic process was evident in both cases. Computerized tomography of the paranasal sinuses and facial bones in patient 1 revealed a small lesion eroding through the inner table of the left mandibular ramus. Microscopic examination of this mass revealed a spindle cell neoplasm with chondroid material, dystrophic calcification, and both osteoclast-like and fibroblast-like cells. Prominent vascularity and marked atypia were present. These features are consistent with a phosphaturic mesenchymal tumor of the mixed connective tissue variant. In the second patient, computerized tomography revealed a lytic lesion located in the right proximal tibia, with histologic features consistent with a phosphaturic mesenchymal tumor of the nonossifying fibroma-like variant. Resection of each tumor resulted in rapid correction of the phosphaturia and healing of the rachitic abnormalities. A careful search for small or occult tumors should be carried out in cases of acquired phosphaturic rickets.
Conference Paper: Connectionist acoustic word models[Show abstract] [Hide abstract]
ABSTRACT: Other researchers have claimed significant improvements to their recognizers by using word models based on data-driven subphonetic units rather than traditional subword models. A possible advantage of this approach is that subphonetic models can be derived automatically from the data, so that the recognizer is trained to discriminate between acoustic categories. The authors describe some of the problems with the units that are derived from acoustic-phonetic considerations (when used for a hidden-Markov-model-based recognizer), and propose a novel technique for constructing acoustic word models using a multilayer perceptron (MLP). The authors are designing a subphonetic unit called the UNnone which is similar to fenones. A vector quantizer is used to partition the acoustic space into a set of clusters. Once the vector quantizer has been designed, the training vectors are compared to the reference vectors using a Euclidean distance measure. The label corresponding to the closest reference vector is assigned to the input vector. These labels are used as targets for training the MLPNeural Networks for Signal Processing  II., Proceedings of the 1992 IEEE-SP Workshop; 01/1992
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ABSTRACT: Tumor-induced osteomalacia (TIO) is a rare and unique syndrome characterized by hypophosphatemia, excessive urinary phosphate excretion, reduced 1,25-dihydroxyvitamin D concentrations, and osteomalacia. Removal of the tumor is associated with a cure of the lesion. Several laboratories have now shown that conditioned medium derived from cultures of such tumors contain a small, heat-sensitive substance ("phosphatonin") of <25,000 daltons that specifically inhibits sodium-dependent phosphate transport in cultured renal proximal tubular epithelia. This substance does not increase cyclic adenosine monophosphate (cAMP) formation in tubular epithelial cells and does not increase cAMP excretion in urine. A substance with similar properties is present in the circulation of patients on hemodialysis. A syndrome with a remarkably similar biochemical phenotype, namely, X-linked hypophosphatemic rickets (XLH), also has a circulating factor with properties similar, if not identical, to those of the tumor-derived factor, "phosphatonin." The molecular defect in XLH has been shown to be due to a mutant endopeptidase, PHEX, whose substrate might be "phosphatonin." Hypophosphatemia and other biochemical abnormalities in TIO are due to excessive production of "phosphatonin" with normal PHEX function, whereas the biochemical abnormalities in XLH are caused by a mutant PHEX enzyme that fails to process "phosphatonin."Bone 10/2000; 27(3):333-8. DOI:10.1016/S8756-3282(00)00334-3 · 3.97 Impact Factor
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ABSTRACT: Stress fractures frequently occur from overtraining. When stress fractures recur, underlying metabolic abnormalities should be ruled out. We report a middle-aged woman in whom such an evaluation demonstrated previously undiagnosed hypophosphatemic rickets after she presented with recurring stress fractures in her feet. Treatment with phosphate and calcitriol was associated with clinical improvement that would likely not have occurred without this intervention. Any patient with recurring stress fractures should be evaluated with several screening laboratory tests, metabolic bone x-rays, and a measurement of bone mineral density.The Journal of Foot and Ankle Surgery 03/2001; 40(2):101-4. DOI:10.1016/S1067-2516(01)80051-X · 0.85 Impact Factor
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