Lobular carcinoma of the breast metastatic to the oral cavity mimicking polymorphous low-grade adenocarcinoma of the minor salivary glands.

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1072, USA.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 02/2000; 124(1):157-9. DOI: 10.1043/0003-9985(2000)124<0157:LCOTBM>2.0.CO;2
Source: PubMed


The oral cavity is a rare site of metastatic lesions; however, metastatic breast carcinoma must be included in the differential diagnosis of tumors of that site in women. We describe a 54-year-old woman who presented with a lesion of the floor of the mouth that histologically resembled polymorphous low-grade adenocarcinoma of the minor salivary glands, which was eventually established to represent metastatic lobular breast carcinoma. The final diagnosis was based on comparison with a primary tumor resected 13 years earlier and immunohistochemical reactivity with antibodies to steroid receptors. Relevant aspects of lobular breast carcinoma, polymorphous low-grade adenocarcinoma, and metastatic oral cavity lesions are discussed.

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    • "Thus, it is a diagnosis of exclusion. They fall broadly into two categories: 1) the occasional low-grade terminal duct/polymorphous adenocarcinoma (PLGA) arising from the intercalated ducts, which microscopically resemble lobular carcinoma of the breast [62] and are most commonly found in the palate, and 2) the high-grade salivary duct adenocarcinoma that arise from the major salivary glands and typically metastasize early and "
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