Sickness in pregnancy and sex of child.

The Lancet (Impact Factor: 39.21). 01/2000; 354(9195):2053. DOI: 10.1016/S0140-6736(99)04239-7
Source: PubMed

ABSTRACT We report a female predominance among the offspring of mothers with hyperemesis gravidarum.

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    ABSTRACT: Reproductive factors have been shown to influence cancer risk. Several pathological conditions during pregnancy have also been associated with subsequent increased cancer risk in the mother. Hyperemesis gravidarum (hyperemesis) is an early pregnancy condition characterized by severe nausea and vomiting resulting in weight loss and metabolic disturbances. Studies have reported associations between hyperemesis and cancer, but results are inconsistent. In this nested case-control study we linked the population-based medical birth registries and cancer registries in Norway, Sweden and Denmark in order to examine overall cancer risk and risk of specific cancer types in women with a history of hyperemesis, using conditional logistic regression. In total, 168,501 cases of cancer in addition to up to 10 cancer-free controls per case were randomly sampled, matched on year of birth and birth registry (n=1,721,626). Hyperemesis was defined through the International Classification of Diseases. Analyses were adjusted for potential confounders. Hyperemesis was inversely associated with overall cancer risk with adjusted relative risk (aRR) of 0.93 (95% CI: 0.88-0.99), with cancer in the lungs (aRR: 0.60, 95% CI: 0.44-0.81), cervix (aRR: 0.66, 95% CI: 0.49-0.91) and rectum (aRR: 0.48, 95% CI: 0.29-0.78). Thyroid cancer was positively associated with hyperemesis (aRR 1.45, 95% CI: 1.06-1.99) and risk increased with more than one hyperemetic pregnancy (aRR 1.80, 95% CI: 1.23-2.63). Hormonal factors, in particular human chorionic gonadotropin, are likely to be involved in mediating these effects. This study is the first to systematically address these associations and provides valuable knowledge on potential long-term consequences of hyperemesis. This article is protected by copyright. All rights reserved. © 2015 UICC.
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    ABSTRACT: Disgust, an emotion triggering behavioral avoidance of pathogens, serves as a first line of defense against infections. Since behavior related to disgust involves some cost, the aversive reaction should be adjusted to the level of an individual's immunocompetence, and raise only when immunological function is lower (e.g. during pregnancy). We studied changes in disgust sensitivity in pregnant women, and tested if disgust sensitivity is related to a fetus's sex. 92 women participated in a three-stage research, answering the Disgust Scale-Revised questionnaire at each trimester of pregnancy. The result showed that total disgust and disgust sensitivity in the Core Domain were the highest in the first trimester (when maternal immunosuppression is also the highest), and decreased during pregnancy in women bearing daughters. Women bearing sons had relatively high disgust sensitivity persisting in the first and in the second trimester. The elevation in disgust sensitivity during the second trimester for mothers bearing male fetus can be explained by the necessity to protect for a longer time, a more ecologically sensitive fetus, and also herself when bearing a more energetically costly sex. The proximate mechanism may involve the differences in maternal testosterone and cortisol concentrations in the second trimester of pregnancy.
    Physiology & Behavior 11/2014; 139. DOI:10.1016/j.physbeh.2014.11.032 · 3.03 Impact Factor
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    ABSTRACT: Hyperemesis gravidarum is a complex condition with a multifactorial etiology characterized by severe intractable nausea and vomiting. Despite a high prevalence, studies exploring underlying etiology and treatments are limited. We performed a literature review, focusing on articles published over the last 10 years, to examine current perspectives and recent developments in hyperemesis gravidarum.
    International Journal of Women's Health 08/2014; 6:719-25. DOI:10.2147/IJWH.S37685