Article

Vaccination of neonatal colostrum-deprived calves against Pasteurella haemolytica A1.

Department of Pathobiology, Ontario Veterinary College, University of Guelph.
Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire (impact factor: 0.94). 02/2000; 64(1):3-8. pp.3-8
Source: PubMed

ABSTRACT Colostrum-deprived Holstein calves were vaccinated at 2 and 4 wk of age with a Pasteurella haemolytica A1 culture supernatant vaccine to determine whether active immune responses and protection could be induced in this age group in the absence of maternal antibodies. All calves responded to vaccination with high titers of IgM antibodies to capsular polysaccharide within 1 wk of primary vaccination. Mean titers of IgG1 and IgG2 antibodies to this antigen increased significantly by 2 wk after secondary vaccination, but peak antibody titers were low. All of the vaccinated calves seroconverted with production of leukotoxin-neutralizing antibodies, but peak antibody titers were low. Vaccinated calves experienced considerable lung damage after experimental challenge, but survival rate, clinical scores, and percent lung involvement were significantly better than those of control (placebo-injected) calves.

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Keywords

active immune responses
 
age group
 
calves
 
clinical scores
 
Colostrum-deprived Holstein calves
 
considerable lung damage
 
experimental challenge
 
IgG2 antibodies
 
maternal antibodies
 
Mean titers
 
Pasteurella haemolytica A1 culture supernatant vaccine
 
peak antibody titers
 
percent lung involvement
 
primary vaccination
 
secondary vaccination
 
Vaccinated calves
 
vaccinated calves seroconverted
 
vaccination
 

D C Hodgins