Article

[Administration of tobramycin aerosols in patients with nosocomial pneumonia: a preliminary study].

Laboratoire d'Antibiologie Expérimentale, Faculté de médecine de Nantes.
La Presse Médicale (impact factor: 0.67). 02/2000; 29(2):76-8. pp.76-8
Source: PubMed

ABSTRACT The aim of this study was to assess renal and respiratory tolerance of aerosolized tobramycin in intubated and mechanically ventilated patients with nosocomial pneumonia.
This was a multicenter, randomized, double-blind, placebo controlled study. Thirty-eight mechanically ventilated patients with documented nosocomial pneumonia were included. Patients treated with intravenous betalactam and tobramycin were randomly allocated to receive aerosolized tobramycin (6 mg/kg/day, n = 21) or placebo (n = 17). The aerosol was administered via a pneumatic nebulizer once a day for 5 days.
Respiratory tolerance was good in all but two patients. No acute renal failure occurred. By day 10, 7 patients in the tobramycin group (35%) had been extubated versus 3 in the placebo group (18.5%, p = 0.18). By day 28, 6 patients had died (2 in the tobramycin group and 4 in the placebo group, p = 0.23).
Aerosolized tobramycin was well tolerated in ventilated patients with documented nosocomial pneumonia.

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Keywords

5 days
 
6 patients
 
7 patients
 
acute renal failure
 
aerosolized tobramycin
 
documented nosocomial pneumonia
 
intravenous betalactam
 
intubated
 
mechanically ventilated patients
 
multicenter
 
nosocomial pneumonia
 
patients
 
placebo
 
placebo group
 
pneumatic nebulizer
 
randomized
 
respiratory tolerance
 
tobramycin
 
tobramycin group
 
ventilated patients