Lack of CD 29 (β1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis

University of Milan, Milano, Lombardy, Italy
Human Pathlogy (Impact Factor: 2.77). 03/2000; 31(2):220-6. DOI: 10.1016/S0046-8177(00)80223-3
Source: PubMed

ABSTRACT Intravascular Lymphomatosis (IL) is a rare and usually aggressive form of non-Hodgkin's lymphoma characterized by the growth of neoplastic cells within vascular lumina that usually presents with skin or central nervous system (CNS) involvement. The mechanism(s) for the selective intravascular growth of this neoplasm remain(s) unexplained. We now report clinical and immunohistologic data on surgical material from 6 cases of IL; in 4 of 6 cases, autopsies were performed. Our IL cases shared the following features: (1) B-cell lineage; (2) lack of skin involvement at presentation; (3) aggressive behavior; and (4) lack of extravascular lymphomatous masses; in addition, 1 case had an associated gastric low-grade MALT lymphoma. We studied by immunohistochemistry formalin-fixed, paraffin-embedded sections with monoclonal antibodies to molecules known to be involved in lymphocyte and endothelial adhesion phenomena, that is, CD29 (beta1 integrin subunit), CD43 (leukosialin), CD44 (H-CAM), CD54 (ICAM-1), embryonal N-CAM (e-NCAM), and EMA (episialin). In all cases, the surfaces of IL aggregates reacted for CD44 but were consistently negative for CD29; also absent was CD54. Conversely, the integrity of the endothelial cells was underscored by their even reactivity for CD29, CD44, and CD54. Given that CD29 is currently regarded as critical for lymphocyte trafficking in general and for transvascular migration in particular, and CD54 is also involved in transvascular lymphocyte migration, we conclude that their consistent absence in IL may contribute to its intravascular and disseminated distribution pattern. The rather frequent association of IL with various conventional lymphomas is known; yet, one of our cases appears to be the first report of IL associated with a low-grade MALT lymphoma.

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    • "La paroi vasculaire peut également être le siège d'une infiltration tumorale sousendothéliale mais une extension parenchymateuse extravasculaire est rare. La propension des cellules tumorales à demeurer intraluminales est en partie expliquée par la perte d'expression de CD29 (␤1-intégrine) et de CD54 (ICAM-1, InterCellular Adhesion Molecule 1), deux protéines de surface indispensables à la migration des lymphocytes à travers la paroi vasculaire [3]. Le LBIV est une maladie ubiquitaire (« homeless lymphoma » [4]), mais, en raison de la présence de récepteurs endothéliaux spécifiques différents selon les organes, on observe une atteinte préférentielle de certains tissus comme le système nerveux ou la peau [5] [6]. "
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    ABSTRACT: Introduction: Intravascular large B cell lymphoma is a neoplastic cell proliferation leading to the occlusion of the lumen of small vessels. This is a rare haematological malignancy, which is difficult to diagnose because of a heterogeneous clinical presentation. Case report: We report a 62-year-old man who presented a macrophage activation syndrome as the presenting manifestation of an intravascular lymphoma. This association is frequently marked by a greater severity and clinical care requires an early and appropriate treatment. Conclusion: Due to the polymorphism and the systemic presentation of intravascular large B cell lymphoma, the internist may be confronted with this disease, which is considered to be more severe if associated with a macrophage activation syndrome. Awareness of the intravascular large B cell lymphoma is important because the prognosis depends on the rapidity of the initiation of chemotherapy associated with rituximab.
    La Revue de Médecine Interne 05/2013; 34(10). DOI:10.1016/j.revmed.2012.10.001 · 1.07 Impact Factor
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    • "This is in a sharp contrast with the finding that adrenal involvement in disseminated non-Hodgkin's lymphoma is rare and occurs in only 4% of cases by CT scan [8]. Although the mechanism of the preferential involvement of lymphoma cells to the adrenal glands in IVLBCL remains unknown, its association with a lack of homing receptors and adhesion molecules, including CD29 (β1 integrin) and CD54 (intercellular adhesion molecule 1), has been hypothesized [9, 10], and this might be one of the distinct characteristics of IVLBCL. "
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    ABSTRACT: Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma. Although the involvement of adrenal glands in IVLBCL is often observed, primary adrenal IVLBCL is rare. Most reported cases of adrenal IVLBCL showed bilateral lesions resulting in rapidly progressive adrenal failure and poor prognosis. Here, we report a case of slowly progressive primary adrenal IVLBCL manifesting initially with unilateral adrenal incidentaloma. This case is a silent IVLBCL and shows that the enlargement of both adrenal glands can be followed.
    Case Reports in Medicine 08/2012; 2012:849285. DOI:10.1155/2012/849285
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    • "The mechanism of selective intravascular location of IVLBCL are largely unknown. Several studies showed that the defective interactions between lymphoma cells and vessels may play a role in the pathogenesis of this disorder [5-7]. Lymphocyes circulating in the blood vessels bind to high endothelial venules (HEV) with lymphocyte homing receptor, traverse vessels walls and enter lymphoid organs. "
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    ABSTRACT: To investigate the clinicopathological features of primary intravascular large B-cell lymphoma of lung. A case of primary pulmonary intravascular large B-cell lymphoma was analysed in histopathology and immunophenotype. The patient is a 42-year-old female who had cough for one year. Computed tomography showed ground-glass opacities and small nodules in bilateral lung fields. Histopathology demonstrated accumulation of similar sized neoplastic cells within alveolar capillaries, widening the alveolar septae. The alveolar structure sustained in part of districtions. Immunohistologically, the tumor cells were positive for CD20 and negative for CD3,CK, which were similar to the diffuse large B-cell lymphoma. Intravascular large B-cell lymphoma is an uncommon type of non-Hodgkin's lymphoma. Primary pulmonary presentation is even more rare. The diagnosis is based on the histopathology and immunohistochemistry. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here:
    Diagnostic Pathology 06/2012; 7(1):70. DOI:10.1186/1746-1596-7-70 · 2.60 Impact Factor
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