Lack of CD 29 (β1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis

University of Milan, Milano, Lombardy, Italy
Human Pathlogy (Impact Factor: 2.77). 03/2000; 31(2):220-6. DOI: 10.1016/S0046-8177(00)80223-3
Source: PubMed


Intravascular Lymphomatosis (IL) is a rare and usually aggressive form of non-Hodgkin's lymphoma characterized by the growth of neoplastic cells within vascular lumina that usually presents with skin or central nervous system (CNS) involvement. The mechanism(s) for the selective intravascular growth of this neoplasm remain(s) unexplained. We now report clinical and immunohistologic data on surgical material from 6 cases of IL; in 4 of 6 cases, autopsies were performed. Our IL cases shared the following features: (1) B-cell lineage; (2) lack of skin involvement at presentation; (3) aggressive behavior; and (4) lack of extravascular lymphomatous masses; in addition, 1 case had an associated gastric low-grade MALT lymphoma. We studied by immunohistochemistry formalin-fixed, paraffin-embedded sections with monoclonal antibodies to molecules known to be involved in lymphocyte and endothelial adhesion phenomena, that is, CD29 (beta1 integrin subunit), CD43 (leukosialin), CD44 (H-CAM), CD54 (ICAM-1), embryonal N-CAM (e-NCAM), and EMA (episialin). In all cases, the surfaces of IL aggregates reacted for CD44 but were consistently negative for CD29; also absent was CD54. Conversely, the integrity of the endothelial cells was underscored by their even reactivity for CD29, CD44, and CD54. Given that CD29 is currently regarded as critical for lymphocyte trafficking in general and for transvascular migration in particular, and CD54 is also involved in transvascular lymphocyte migration, we conclude that their consistent absence in IL may contribute to its intravascular and disseminated distribution pattern. The rather frequent association of IL with various conventional lymphomas is known; yet, one of our cases appears to be the first report of IL associated with a low-grade MALT lymphoma.

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    • "La paroi vasculaire peut également être le siège d'une infiltration tumorale sousendothéliale mais une extension parenchymateuse extravasculaire est rare. La propension des cellules tumorales à demeurer intraluminales est en partie expliquée par la perte d'expression de CD29 (␤1-intégrine) et de CD54 (ICAM-1, InterCellular Adhesion Molecule 1), deux protéines de surface indispensables à la migration des lymphocytes à travers la paroi vasculaire [3]. Le LBIV est une maladie ubiquitaire (« homeless lymphoma » [4]), mais, en raison de la présence de récepteurs endothéliaux spécifiques différents selon les organes, on observe une atteinte préférentielle de certains tissus comme le système nerveux ou la peau [5] [6]. "
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    ABSTRACT: Introduction: Intravascular large B cell lymphoma is a neoplastic cell proliferation leading to the occlusion of the lumen of small vessels. This is a rare haematological malignancy, which is difficult to diagnose because of a heterogeneous clinical presentation. Case report: We report a 62-year-old man who presented a macrophage activation syndrome as the presenting manifestation of an intravascular lymphoma. This association is frequently marked by a greater severity and clinical care requires an early and appropriate treatment. Conclusion: Due to the polymorphism and the systemic presentation of intravascular large B cell lymphoma, the internist may be confronted with this disease, which is considered to be more severe if associated with a macrophage activation syndrome. Awareness of the intravascular large B cell lymphoma is important because the prognosis depends on the rapidity of the initiation of chemotherapy associated with rituximab.
    La Revue de Médecine Interne 05/2013; 34(10). DOI:10.1016/j.revmed.2012.10.001 · 1.07 Impact Factor
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    • "This is in a sharp contrast with the finding that adrenal involvement in disseminated non-Hodgkin's lymphoma is rare and occurs in only 4% of cases by CT scan [8]. Although the mechanism of the preferential involvement of lymphoma cells to the adrenal glands in IVLBCL remains unknown, its association with a lack of homing receptors and adhesion molecules, including CD29 (β1 integrin) and CD54 (intercellular adhesion molecule 1), has been hypothesized [9, 10], and this might be one of the distinct characteristics of IVLBCL. "
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    ABSTRACT: Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma. Although the involvement of adrenal glands in IVLBCL is often observed, primary adrenal IVLBCL is rare. Most reported cases of adrenal IVLBCL showed bilateral lesions resulting in rapidly progressive adrenal failure and poor prognosis. Here, we report a case of slowly progressive primary adrenal IVLBCL manifesting initially with unilateral adrenal incidentaloma. This case is a silent IVLBCL and shows that the enlargement of both adrenal glands can be followed.
    Case Reports in Medicine 08/2012; 2012:849285. DOI:10.1155/2012/849285
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    • "Rare cases with T-cell or NK-cell phenotype [12] [13] [14] have been reported. The intravascular growth pattern is postulated to be resulted from defects in surface receptors for extravascular migration, lack of CD29 and CD54 adhesion molecules, and lack of leukocyte surface glycoprotein CD18 [15]. IVBL is almost always a diagnostic challenge , both clinically and pathologically, and post mortem diagnoses are not uncommon. "
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    ABSTRACT: Intravascular lymphoma is an aggressive and extremely rare extranodal lymphoma with neoplastic lymphoid cells confined exclusively within intravascular spaces. The histopathologic findings are subtle due to the rarity of the neoplastic cells in blood vessels. Clinical presentations are non-specific and focal space-occupying lesions or lymphoadenopathy are always lacking. It is a diagnostic challenge. Secondary hemophagocytic syndrome is uncommon and is typically associated with infection, malignancy, and suppressed immune states. Intravascular lymphoma has a strong association with hemophagocytic syndrome in Asian patients, the so-called "Asian variant", but not in Western patients. We report a case of intravascular B-cell lymphoma in a Caucasian patient associated with secondary hemophagocytic syndrome. The patient was diagnosed by core liver biopsy and successfully treated. This case demonstrates the importance of high index of suspicion and astute histopathologic examination in recognition of this unusual clinical and pathologic combination.
    International journal of clinical and experimental pathology 07/2012; 5(5):448-54. · 1.89 Impact Factor
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