Estrogen and progesterone receptors in colon tumors.
ABSTRACT Existing data suggest that there is a hormonal basis to the cause of colon cancer. In the present study, we evaluated the presence of estrogen receptors (ERs) and progesterone receptors (PRs) in colonic tumors from 156 women diagnosed with colon cancer in Utah from September 1991 through September 1994. Immunohistochemical staining with antibodies to ERs and PRs was performed on histologic sections prepared from paraffin blocks. None of the tumors were considered ER-positive; 1 tumor was PR-positive. Use of hormone replacement therapy was not associated with PR-positive tumors. These data do not support previous reports that suggest that colon tumors frequently have receptors for estrogen, progesterone, or both.
SourceAvailable from: Marwa Khairy[Show abstract] [Hide abstract]
ABSTRACT: Background: incidence of Colorectal cancer (CRC) is increasing globally. In Egypt, CRC ranks the sixth most common cancer in males and the fifth in females. Aim: To assess the expression of estrogen receptors (alpha and beta) in pre-malignant (adenomatous po-lyps and IBD), malignant colorectal lesions and nor-mal colonic mucosa in group of Egyptian patients. Methods: This prospective study was done on 45 pa-tients presenting with colonic symptoms, patients were divided into four groups; 15 CRC patients, 10 patients with adenomatous polyps, 10 IBD patients and 10 patients in the control group. Patients sub-jected to: Stool analysis, FOBT, CBC, CEA, Abdomi-nal ultrasound & colonoscopy and biopsy (number = 80), Pathological, immunohistochemistry and RT-PCR quantification of ERα and ERβ were done. Re-sults: Mean age: 39.2 (12 -73), gender: M/F: 28/17. Bleeding per rectum was the commonest presentation; 29/45 (64.4%). CEA was significantly elevated in the CRC group compared with other studied groups (1692 mg/L vs. 4.0, 4.0 and 4.4 mg/L). Ultrasonography of the studied patients showed that metastatic CRC: 3/15 (20%); Colonic wall thickening: 5/15 (33.3%), 1/10 showed colonic polypoidal lesions in adenoma-tous polyps groups, in IBD group: 4/10 (40%) showed colonic and ileocecal thicknening. All the studied pa-tients showed negative results for estrogen receptors (alpha and beta) by the use of immunohistochemistry staining and RT-PCR technique. Conclusion: Role of estrogen receptors in the colonic mucosa, precancer-ous and colorectal cancer is doubtful, contradictory results with some literature data could be due to ra-cial and genetic difference in the studied population.Open Journal of Gastroenterology 04/2013; 3(02). DOI:10.4236/ojgas.2013.32026
Iranian Journal of Obstetrics, Gynecology and Infertility 01/2009;
[Show abstract] [Hide abstract]
ABSTRACT: El cáncer colorrectal asociado al embarazo es una patología extremadamente infrecuente. Se presenta el caso de una paciente de 38 años con antecedentes familiares de cáncer de colon, cursando un embarazo de 35 semanas en la que se diagnosticó un cáncer de colon derecho. Se efectúa una revisión de la literatura en relación al diagnóstico y manejo de esta rara entidad.Revista Chilena de Obstetricia y Ginecologia 01/2008; 73(1). DOI:10.4067/S0717-75262008000100009