Article

Effects of Re-arterialization on early graft function and regeneration in the rat model of heterotopic auxiliary liver transplantation.

Division of Experimental Surgery, Department of Surgery, University Hospital of Ghent, Belgium.
European Surgical Research (Impact Factor: 1.43). 02/2000; 32(1):11-7. DOI: 10.1159/000008735
Source: PubMed

ABSTRACT In the rat model of heterotopic auxiliary liver transplantation, graft re-arterialization may influence the outcome of inter-liver competition. This was investigated in the current study using two transplanted groups with or without graft re-arterialization. Immediately after reperfusion, the re-arterialized grafts showed significantly higher bile flow rate and bilirubin excretion than the grafts without re-arterialization. DNA synthesis rate was also increased more drastically in the re-arterialized group following the transplantation. Without re-arterialization, the rats developed more pronounced cytolysis and cholestasis. Among the long-term survivors, all healthy re-arterialized grafts regenerated, whereas 5/6 non-re-arterialized grafts atrophied. These data demonstrate that the re-arterialization increases graft survival by improving early hepatic function, enhancing regenerative response and preventing post-transplant biliary complications in this rat model.

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