[Show abstract][Hide abstract] ABSTRACT: The present study evaluated the antioxidant and antimicrobial activities of raw and processed fruit extracts from Solanum torvum, S.
xanthocarpum and S. violaceum and assessed the relationship with their total phenolic content. Total phenolic and tannin contents of raw
and processed fruit sample extracts ranged from 5.0-7.6 g/100g and 4.5-7.0 g/100g, respectively. As compared to raw samples, processed
samples had significant decrease in total phenolic and tannin content, FRAP, linoleic acid emulsion system, antihaemolytic and superoxide
anion radical scavenging activity. However, processing the samples caused significant (p<0.05) increases in DPPH
scavenging capacities, metal chelating ability and phosphomolybdenum assay. After processing, the total antioxidant activity increased or
remained unchanged depending on the type of samples. All the fruit samples showed optimal antimicrobial activity against Gram negative
bacteria. Interestingly, the extracts from raw and processed S. torvum showed no inhibitory effect on the growth of E. coli.
Journal of Food and Drug Analysis 06/2012; 20(4):844-854. · 0.40 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Anxiety is one of the commonest psychiatric disorders and a large number of medicinal plants have been explored to treat this disorder.Anxiolytic-like action of methanolic extract of the seeds of Solanum torvum (ST) were studied in Swiss albino mice using elevated plus maze (EPM), light and dark transition apparatus (LDA), hole board apparatus (HBA) and marble burying test (MBT).In addition, the effect of Prazocin (62.5 µg/kg, i.p.), an alpha adrenoceptor antagonist; p-chlorophenylalanine (100 mg/kg, i.p.), an inhibitor of serotonin synthesis and haloperidol (50 µg/kg, i.p.), a D2 receptor antagonist on anxiolytic-like effect of ST in above four models were also studied. The effect of ST on PTZ (60 mg/kg, i.p) induced seizures was also studied. Methanolic extract of Solanum torvum (ST-10, 30 and 100 mg/kg) and its ethyl acetate fraction (EAF-10, 30 mg/kg) showed significant increase in open arm exploration, time spent in lit zone, number of head dips and significant decrease in no. of marbles buried in EPM, LDA, HBA and MBT respectively. Prazosin, p-chlorophenylalanine and haloperidol significantly reversed the ST induced anxiolytic effect in EPM, LDA, HBA and MBT. The extracts also protected animal against PTZ-induced seizures.These results suggest that anxiolytic like effect of ST facilitated the effects of adrenergic, serotonergic, dopaminergic and GABAminergic systems.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.