[Show abstract][Hide abstract] ABSTRACT: Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic data. The antimicrobial activity was screened using five Gram-positive bacteria, six Gram-negative bacteria, seven clinical isolates and four fungi. Antimycobacterial activity was screened against two Mycobacterium strains. The zone of inhibition by methyl caffeate ranged from 0 to 22 mm. The lowest minimum inhibitory concentration (MIC) values of methyl caffeate were: 50 μg/ml against P. vulgaris, 25 μg/ml against K. pneumoniae (ESBL-3971), 8 μg/ml against M. tuberculosis (H(37)Rv) and 8 μg/ml against M. tuberculosis (Rif(R)). Methyl caffeate showed moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate can be evaluated further for drug development.
Indian Journal of Microbiology 12/2012; 52(4):676-681. · 0.46 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The present study evaluated the antioxidant and antimicrobial activities of raw and processed fruit extracts from Solanum torvum, S.
xanthocarpum and S. violaceum and assessed the relationship with their total phenolic content. Total phenolic and tannin contents of raw
and processed fruit sample extracts ranged from 5.0-7.6 g/100g and 4.5-7.0 g/100g, respectively. As compared to raw samples, processed
samples had significant decrease in total phenolic and tannin content, FRAP, linoleic acid emulsion system, antihaemolytic and superoxide
anion radical scavenging activity. However, processing the samples caused significant (p<0.05) increases in DPPH
scavenging capacities, metal chelating ability and phosphomolybdenum assay. After processing, the total antioxidant activity increased or
remained unchanged depending on the type of samples. All the fruit samples showed optimal antimicrobial activity against Gram negative
bacteria. Interestingly, the extracts from raw and processed S. torvum showed no inhibitory effect on the growth of E. coli.
Journal of Food and Drug Analysis 06/2012; 20(4):844-854. · 0.33 Impact Factor
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